A Case of Adalimumab-associated Pancytopenia and Reversible Lymphadenopathy

Adalimumab is a recombinant monoclonal antibody to tumor necrosis factor alpha (TNFα) used in the treatment of inflammatory and autoimmune conditions, including ulcerative colitis (UC). Adverse side effects include infection and injection-site cutaneous reactions; however, rare adverse events such a...

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Autores principales: Walsh, Leonard T, Patel, Ravi, Loloi, Justin, Jones, Kirk, Caler, Julie, Ayaz, Zain, Jain, Rohit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2018
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318094/
https://www.ncbi.nlm.nih.gov/pubmed/30648028
http://dx.doi.org/10.7759/cureus.3477
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author Walsh, Leonard T
Patel, Ravi
Loloi, Justin
Jones, Kirk
Caler, Julie
Ayaz, Zain
Jain, Rohit
author_facet Walsh, Leonard T
Patel, Ravi
Loloi, Justin
Jones, Kirk
Caler, Julie
Ayaz, Zain
Jain, Rohit
author_sort Walsh, Leonard T
collection PubMed
description Adalimumab is a recombinant monoclonal antibody to tumor necrosis factor alpha (TNFα) used in the treatment of inflammatory and autoimmune conditions, including ulcerative colitis (UC). Adverse side effects include infection and injection-site cutaneous reactions; however, rare adverse events such as pancytopenia have been recorded. Here we describe a case of pancytopenia and reversible lymphadenopathy related to adalimumab administration in a patient with UC.
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spelling pubmed-63180942019-01-15 A Case of Adalimumab-associated Pancytopenia and Reversible Lymphadenopathy Walsh, Leonard T Patel, Ravi Loloi, Justin Jones, Kirk Caler, Julie Ayaz, Zain Jain, Rohit Cureus Internal Medicine Adalimumab is a recombinant monoclonal antibody to tumor necrosis factor alpha (TNFα) used in the treatment of inflammatory and autoimmune conditions, including ulcerative colitis (UC). Adverse side effects include infection and injection-site cutaneous reactions; however, rare adverse events such as pancytopenia have been recorded. Here we describe a case of pancytopenia and reversible lymphadenopathy related to adalimumab administration in a patient with UC. Cureus 2018-10-22 /pmc/articles/PMC6318094/ /pubmed/30648028 http://dx.doi.org/10.7759/cureus.3477 Text en Copyright © 2018, Walsh et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Walsh, Leonard T
Patel, Ravi
Loloi, Justin
Jones, Kirk
Caler, Julie
Ayaz, Zain
Jain, Rohit
A Case of Adalimumab-associated Pancytopenia and Reversible Lymphadenopathy
title A Case of Adalimumab-associated Pancytopenia and Reversible Lymphadenopathy
title_full A Case of Adalimumab-associated Pancytopenia and Reversible Lymphadenopathy
title_fullStr A Case of Adalimumab-associated Pancytopenia and Reversible Lymphadenopathy
title_full_unstemmed A Case of Adalimumab-associated Pancytopenia and Reversible Lymphadenopathy
title_short A Case of Adalimumab-associated Pancytopenia and Reversible Lymphadenopathy
title_sort case of adalimumab-associated pancytopenia and reversible lymphadenopathy
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318094/
https://www.ncbi.nlm.nih.gov/pubmed/30648028
http://dx.doi.org/10.7759/cureus.3477
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