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The Synergistic Effect of Immune Checkpoint Blockade and Radiotherapy in Recurrent/Metastatic Sinonasal Cancer
Treatment options for recurrent/metastatic sinonasal cancer (RMSNC) patients are limited. We present two cases with RMSNC treated with a combination of immune checkpoint blockade and hypo-fractionated stereotactic radiotherapy (HSRT). Case 1 presented with RMSNC three months after the primary treat...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318133/ https://www.ncbi.nlm.nih.gov/pubmed/30648054 http://dx.doi.org/10.7759/cureus.3519 |
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author | Yazici, Gozde Gullu, Ibrahim Cengiz, Mustafa Elmali, Aysenur Yilmaz, Melek Tugce Aksoy, Secan Yuce Sari, Sezin Ozyigit, Gokhan |
author_facet | Yazici, Gozde Gullu, Ibrahim Cengiz, Mustafa Elmali, Aysenur Yilmaz, Melek Tugce Aksoy, Secan Yuce Sari, Sezin Ozyigit, Gokhan |
author_sort | Yazici, Gozde |
collection | PubMed |
description | Treatment options for recurrent/metastatic sinonasal cancer (RMSNC) patients are limited. We present two cases with RMSNC treated with a combination of immune checkpoint blockade and hypo-fractionated stereotactic radiotherapy (HSRT). Case 1 presented with RMSNC three months after the primary treatment. The patient progressed under first-line chemotherapy and pembrolizumab was offered. The disease progressed after the sixth cycle. We performed reirradiation with HSRT to the primary site. Case 2 presented with local recurrence eight years after the primary treatment for maxillary sinus cancer. He refused surgery and chemotherapy and was offered nivolumab treatment. After two doses, we performed reirradiation with HSRT. Case 1 showed regression at both the local and the metastatic sites after radiotherapy. The second patient’s symptoms resolved completely three months after radiotherapy. The HSRT and immune checkpoint blockade combination is a promising treatment option for patients with RMSNC. |
format | Online Article Text |
id | pubmed-6318133 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-63181332019-01-15 The Synergistic Effect of Immune Checkpoint Blockade and Radiotherapy in Recurrent/Metastatic Sinonasal Cancer Yazici, Gozde Gullu, Ibrahim Cengiz, Mustafa Elmali, Aysenur Yilmaz, Melek Tugce Aksoy, Secan Yuce Sari, Sezin Ozyigit, Gokhan Cureus Radiation Oncology Treatment options for recurrent/metastatic sinonasal cancer (RMSNC) patients are limited. We present two cases with RMSNC treated with a combination of immune checkpoint blockade and hypo-fractionated stereotactic radiotherapy (HSRT). Case 1 presented with RMSNC three months after the primary treatment. The patient progressed under first-line chemotherapy and pembrolizumab was offered. The disease progressed after the sixth cycle. We performed reirradiation with HSRT to the primary site. Case 2 presented with local recurrence eight years after the primary treatment for maxillary sinus cancer. He refused surgery and chemotherapy and was offered nivolumab treatment. After two doses, we performed reirradiation with HSRT. Case 1 showed regression at both the local and the metastatic sites after radiotherapy. The second patient’s symptoms resolved completely three months after radiotherapy. The HSRT and immune checkpoint blockade combination is a promising treatment option for patients with RMSNC. Cureus 2018-10-29 /pmc/articles/PMC6318133/ /pubmed/30648054 http://dx.doi.org/10.7759/cureus.3519 Text en Copyright © 2018, Yazici et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Radiation Oncology Yazici, Gozde Gullu, Ibrahim Cengiz, Mustafa Elmali, Aysenur Yilmaz, Melek Tugce Aksoy, Secan Yuce Sari, Sezin Ozyigit, Gokhan The Synergistic Effect of Immune Checkpoint Blockade and Radiotherapy in Recurrent/Metastatic Sinonasal Cancer |
title | The Synergistic Effect of Immune Checkpoint Blockade and Radiotherapy in Recurrent/Metastatic Sinonasal Cancer |
title_full | The Synergistic Effect of Immune Checkpoint Blockade and Radiotherapy in Recurrent/Metastatic Sinonasal Cancer |
title_fullStr | The Synergistic Effect of Immune Checkpoint Blockade and Radiotherapy in Recurrent/Metastatic Sinonasal Cancer |
title_full_unstemmed | The Synergistic Effect of Immune Checkpoint Blockade and Radiotherapy in Recurrent/Metastatic Sinonasal Cancer |
title_short | The Synergistic Effect of Immune Checkpoint Blockade and Radiotherapy in Recurrent/Metastatic Sinonasal Cancer |
title_sort | synergistic effect of immune checkpoint blockade and radiotherapy in recurrent/metastatic sinonasal cancer |
topic | Radiation Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318133/ https://www.ncbi.nlm.nih.gov/pubmed/30648054 http://dx.doi.org/10.7759/cureus.3519 |
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