Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies

Chronic kidney disease (CKD) affects ~10% of the global population, with considerable ethnic differences in prevalence and aetiology. We assemble genome-wide association studies of estimated glomerular filtration rate (eGFR), a measure of kidney function that defines CKD, in 312,468 individuals of d...

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Detalles Bibliográficos
Autores principales: Morris, Andrew P., Le, Thu H., Wu, Haojia, Akbarov, Artur, van der Most, Peter J., Hemani, Gibran, Smith, George Davey, Mahajan, Anubha, Gaulton, Kyle J., Nadkarni, Girish N., Valladares-Salgado, Adan, Wacher-Rodarte, Niels, Mychaleckyj, Josyf C., Dueker, Nicole D., Guo, Xiuqing, Hai, Yang, Haessler, Jeffrey, Kamatani, Yoichiro, Stilp, Adrienne M., Zhu, Gu, Cook, James P., Ärnlöv, Johan, Blanton, Susan H., de Borst, Martin H., Bottinger, Erwin P., Buchanan, Thomas A., Cechova, Sylvia, Charchar, Fadi J., Chu, Pei-Lun, Damman, Jeffrey, Eales, James, Gharavi, Ali G., Giedraitis, Vilmantas, Heath, Andrew C., Ipp, Eli, Kiryluk, Krzysztof, Kramer, Holly J., Kubo, Michiaki, Larsson, Anders, Lindgren, Cecilia M., Lu, Yingchang, Madden, Pamela A. F., Montgomery, Grant W., Papanicolaou, George J., Raffel, Leslie J., Sacco, Ralph L., Sanchez, Elena, Stark, Holger, Sundstrom, Johan, Taylor, Kent D., Xiang, Anny H., Zivkovic, Aleksandra, Lind, Lars, Ingelsson, Erik, Martin, Nicholas G., Whitfield, John B., Cai, Jianwen, Laurie, Cathy C., Okada, Yukinori, Matsuda, Koichi, Kooperberg, Charles, Chen, Yii-Der Ida, Rundek, Tatjana, Rich, Stephen S., Loos, Ruth J. F., Parra, Esteban J., Cruz, Miguel, Rotter, Jerome I., Snieder, Harold, Tomaszewski, Maciej, Humphreys, Benjamin D., Franceschini, Nora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318312/
https://www.ncbi.nlm.nih.gov/pubmed/30604766
http://dx.doi.org/10.1038/s41467-018-07867-7

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