Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response

Molecular mechanisms driving disease course and response to therapy in ulcerative colitis (UC) are not well understood. Here, we use RNAseq to define pre-treatment rectal gene expression, and fecal microbiota profiles, in 206 pediatric UC patients receiving standardised therapy. We validate our key...

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Detalles Bibliográficos
Autores principales: Haberman, Yael, Karns, Rebekah, Dexheimer, Phillip J., Schirmer, Melanie, Somekh, Judith, Jurickova, Ingrid, Braun, Tzipi, Novak, Elizabeth, Bauman, Laura, Collins, Margaret H., Mo, Angela, Rosen, Michael J., Bonkowski, Erin, Gotman, Nathan, Marquis, Alison, Nistel, Mason, Rufo, Paul A., Baker, Susan S., Sauer, Cary G., Markowitz, James, Pfefferkorn, Marian D., Rosh, Joel R., Boyle, Brendan M., Mack, David R., Baldassano, Robert N., Shah, Sapana, Leleiko, Neal S., Heyman, Melvin B., Grifiths, Anne M., Patel, Ashish S., Noe, Joshua D., Aronow, Bruce J., Kugathasan, Subra, Walters, Thomas D., Gibson, Greg, Thomas, Sonia Davis, Mollen, Kevin, Shen-Orr, Shai, Huttenhower, Curtis, Xavier, Ramnik J., Hyams, Jeffrey S., Denson, Lee A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318335/
https://www.ncbi.nlm.nih.gov/pubmed/30604764
http://dx.doi.org/10.1038/s41467-018-07841-3

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