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Hypertension and frailty: a systematic review and meta-analysis
OBJECTIVE: To review the association between hypertension and frailty in observational studies. DESIGN: A systematic review of the PubMed, Web of Science and Embase databases was performed. A meta-analysis was performed if at least three studies used the same definition of frailty and a dichotomous...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318510/ https://www.ncbi.nlm.nih.gov/pubmed/30593554 http://dx.doi.org/10.1136/bmjopen-2018-024406 |
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author | Vetrano, Davide L Palmer, Katie M Galluzzo, Lucia Giampaoli, Simona Marengoni, Alessandra Bernabei, Roberto Onder, Graziano |
author_facet | Vetrano, Davide L Palmer, Katie M Galluzzo, Lucia Giampaoli, Simona Marengoni, Alessandra Bernabei, Roberto Onder, Graziano |
author_sort | Vetrano, Davide L |
collection | PubMed |
description | OBJECTIVE: To review the association between hypertension and frailty in observational studies. DESIGN: A systematic review of the PubMed, Web of Science and Embase databases was performed. A meta-analysis was performed if at least three studies used the same definition of frailty and a dichotomous definition of hypertension. SETTING, PARTICIPANTS AND MEASURES: Studies providing information on the association between frailty and hypertension in adult persons, regardless of the study setting, study design or definition of hypertension and frailty were included. RESULTS: Among the initial 964 articles identified, 27 were included in the review. Four longitudinal studies examined the incidence of frailty according to baseline hypertension status, providing conflicting results. Twenty-three studies assessed the cross-sectional association between frailty and hypertension: 13 of them reported a significantly higher prevalence of frailty in hypertensive participants and 10 found no significant association. The pooled prevalence of hypertension in frail individuals was 72% (95% CI 66% to 79%) and the pooled prevalence of frailty in individuals with hypertension was 14% (95% CI 12% to 17%). Five studies, including a total of 7656 participants, reported estimates for the association between frailty and hypertension (pooled OR 1.33; 95% CI 0.94 to 1.89). CONCLUSIONS: Frailty is common in persons with hypertension. Given the possible influence of frailty on the risk–benefit ratio of treatment for hypertension and its high prevalence, it is important to assess the presence of this condition in persons with hypertension. TRIAL REGISTRATION NUMBER: CRD42017058303. |
format | Online Article Text |
id | pubmed-6318510 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-63185102019-01-14 Hypertension and frailty: a systematic review and meta-analysis Vetrano, Davide L Palmer, Katie M Galluzzo, Lucia Giampaoli, Simona Marengoni, Alessandra Bernabei, Roberto Onder, Graziano BMJ Open Geriatric Medicine OBJECTIVE: To review the association between hypertension and frailty in observational studies. DESIGN: A systematic review of the PubMed, Web of Science and Embase databases was performed. A meta-analysis was performed if at least three studies used the same definition of frailty and a dichotomous definition of hypertension. SETTING, PARTICIPANTS AND MEASURES: Studies providing information on the association between frailty and hypertension in adult persons, regardless of the study setting, study design or definition of hypertension and frailty were included. RESULTS: Among the initial 964 articles identified, 27 were included in the review. Four longitudinal studies examined the incidence of frailty according to baseline hypertension status, providing conflicting results. Twenty-three studies assessed the cross-sectional association between frailty and hypertension: 13 of them reported a significantly higher prevalence of frailty in hypertensive participants and 10 found no significant association. The pooled prevalence of hypertension in frail individuals was 72% (95% CI 66% to 79%) and the pooled prevalence of frailty in individuals with hypertension was 14% (95% CI 12% to 17%). Five studies, including a total of 7656 participants, reported estimates for the association between frailty and hypertension (pooled OR 1.33; 95% CI 0.94 to 1.89). CONCLUSIONS: Frailty is common in persons with hypertension. Given the possible influence of frailty on the risk–benefit ratio of treatment for hypertension and its high prevalence, it is important to assess the presence of this condition in persons with hypertension. TRIAL REGISTRATION NUMBER: CRD42017058303. BMJ Publishing Group 2018-12-28 /pmc/articles/PMC6318510/ /pubmed/30593554 http://dx.doi.org/10.1136/bmjopen-2018-024406 Text en © Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Geriatric Medicine Vetrano, Davide L Palmer, Katie M Galluzzo, Lucia Giampaoli, Simona Marengoni, Alessandra Bernabei, Roberto Onder, Graziano Hypertension and frailty: a systematic review and meta-analysis |
title | Hypertension and frailty: a systematic review and meta-analysis |
title_full | Hypertension and frailty: a systematic review and meta-analysis |
title_fullStr | Hypertension and frailty: a systematic review and meta-analysis |
title_full_unstemmed | Hypertension and frailty: a systematic review and meta-analysis |
title_short | Hypertension and frailty: a systematic review and meta-analysis |
title_sort | hypertension and frailty: a systematic review and meta-analysis |
topic | Geriatric Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318510/ https://www.ncbi.nlm.nih.gov/pubmed/30593554 http://dx.doi.org/10.1136/bmjopen-2018-024406 |
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