Carbamate-Based Bolaamphiphile as Low-Molecular-Weight Hydrogelators

A new bolaamphiphile analog featuring carbamate moieties was synthesized in six steps starting from thymidine. The amphiphile structure exhibits nucleoside-sugar polar heads attached to a hydrophobic spacer via carbamate (urethane) functions. This molecular structure, which possesses additional H-bo...

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Detalles Bibliográficos
Autores principales: Latxague, Laurent, Gaubert, Alexandra, Maleville, David, Baillet, Julie, Ramin, Michael A., Barthélémy, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318576/
https://www.ncbi.nlm.nih.gov/pubmed/30674156
http://dx.doi.org/10.3390/gels2040025
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author Latxague, Laurent
Gaubert, Alexandra
Maleville, David
Baillet, Julie
Ramin, Michael A.
Barthélémy, Philippe
author_facet Latxague, Laurent
Gaubert, Alexandra
Maleville, David
Baillet, Julie
Ramin, Michael A.
Barthélémy, Philippe
author_sort Latxague, Laurent
collection PubMed
description A new bolaamphiphile analog featuring carbamate moieties was synthesized in six steps starting from thymidine. The amphiphile structure exhibits nucleoside-sugar polar heads attached to a hydrophobic spacer via carbamate (urethane) functions. This molecular structure, which possesses additional H-bonding capabilities, induces the stabilization of low-molecular-weight gels (LMWGs) in water. The rheological studies revealed that the new bolaamphiphile 7 stabilizes thixotropic hydrogels with a high elastic modulus (G′ > 50 kPa).
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spelling pubmed-63185762019-01-17 Carbamate-Based Bolaamphiphile as Low-Molecular-Weight Hydrogelators Latxague, Laurent Gaubert, Alexandra Maleville, David Baillet, Julie Ramin, Michael A. Barthélémy, Philippe Gels Communication A new bolaamphiphile analog featuring carbamate moieties was synthesized in six steps starting from thymidine. The amphiphile structure exhibits nucleoside-sugar polar heads attached to a hydrophobic spacer via carbamate (urethane) functions. This molecular structure, which possesses additional H-bonding capabilities, induces the stabilization of low-molecular-weight gels (LMWGs) in water. The rheological studies revealed that the new bolaamphiphile 7 stabilizes thixotropic hydrogels with a high elastic modulus (G′ > 50 kPa). MDPI 2016-09-28 /pmc/articles/PMC6318576/ /pubmed/30674156 http://dx.doi.org/10.3390/gels2040025 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Latxague, Laurent
Gaubert, Alexandra
Maleville, David
Baillet, Julie
Ramin, Michael A.
Barthélémy, Philippe
Carbamate-Based Bolaamphiphile as Low-Molecular-Weight Hydrogelators
title Carbamate-Based Bolaamphiphile as Low-Molecular-Weight Hydrogelators
title_full Carbamate-Based Bolaamphiphile as Low-Molecular-Weight Hydrogelators
title_fullStr Carbamate-Based Bolaamphiphile as Low-Molecular-Weight Hydrogelators
title_full_unstemmed Carbamate-Based Bolaamphiphile as Low-Molecular-Weight Hydrogelators
title_short Carbamate-Based Bolaamphiphile as Low-Molecular-Weight Hydrogelators
title_sort carbamate-based bolaamphiphile as low-molecular-weight hydrogelators
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318576/
https://www.ncbi.nlm.nih.gov/pubmed/30674156
http://dx.doi.org/10.3390/gels2040025
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