Evaluation of Hydrogels Based on Oxidized Hyaluronic Acid for Bioprinting

In this study, we evaluate hydrogels based on oxidized hyaluronic acid, cross-linked with adipic acid dihydrazide, for their suitability as bioinks for 3D bioprinting. Aldehyde containing hyaluronic acid (AHA) is synthesized and cross-linked via Schiff Base chemistry with bifunctional adipic acid di...

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Detalles Bibliográficos
Autores principales: Weis, Matthias, Shan, Junwen, Kuhlmann, Matthias, Jungst, Tomasz, Tessmar, Jörg, Groll, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318583/
https://www.ncbi.nlm.nih.gov/pubmed/30674858
http://dx.doi.org/10.3390/gels4040082
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author Weis, Matthias
Shan, Junwen
Kuhlmann, Matthias
Jungst, Tomasz
Tessmar, Jörg
Groll, Jürgen
author_facet Weis, Matthias
Shan, Junwen
Kuhlmann, Matthias
Jungst, Tomasz
Tessmar, Jörg
Groll, Jürgen
author_sort Weis, Matthias
collection PubMed
description In this study, we evaluate hydrogels based on oxidized hyaluronic acid, cross-linked with adipic acid dihydrazide, for their suitability as bioinks for 3D bioprinting. Aldehyde containing hyaluronic acid (AHA) is synthesized and cross-linked via Schiff Base chemistry with bifunctional adipic acid dihydrazide (ADH) to form a mechanically stable hydrogel with good printability. Mechanical and rheological properties of the printed and casted hydrogels are tunable depending on the concentrations of AHA and ADH cross-linkers.
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spelling pubmed-63185832019-01-17 Evaluation of Hydrogels Based on Oxidized Hyaluronic Acid for Bioprinting Weis, Matthias Shan, Junwen Kuhlmann, Matthias Jungst, Tomasz Tessmar, Jörg Groll, Jürgen Gels Communication In this study, we evaluate hydrogels based on oxidized hyaluronic acid, cross-linked with adipic acid dihydrazide, for their suitability as bioinks for 3D bioprinting. Aldehyde containing hyaluronic acid (AHA) is synthesized and cross-linked via Schiff Base chemistry with bifunctional adipic acid dihydrazide (ADH) to form a mechanically stable hydrogel with good printability. Mechanical and rheological properties of the printed and casted hydrogels are tunable depending on the concentrations of AHA and ADH cross-linkers. MDPI 2018-10-09 /pmc/articles/PMC6318583/ /pubmed/30674858 http://dx.doi.org/10.3390/gels4040082 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Weis, Matthias
Shan, Junwen
Kuhlmann, Matthias
Jungst, Tomasz
Tessmar, Jörg
Groll, Jürgen
Evaluation of Hydrogels Based on Oxidized Hyaluronic Acid for Bioprinting
title Evaluation of Hydrogels Based on Oxidized Hyaluronic Acid for Bioprinting
title_full Evaluation of Hydrogels Based on Oxidized Hyaluronic Acid for Bioprinting
title_fullStr Evaluation of Hydrogels Based on Oxidized Hyaluronic Acid for Bioprinting
title_full_unstemmed Evaluation of Hydrogels Based on Oxidized Hyaluronic Acid for Bioprinting
title_short Evaluation of Hydrogels Based on Oxidized Hyaluronic Acid for Bioprinting
title_sort evaluation of hydrogels based on oxidized hyaluronic acid for bioprinting
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318583/
https://www.ncbi.nlm.nih.gov/pubmed/30674858
http://dx.doi.org/10.3390/gels4040082
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