Cargando…
Low-Cost Microfluidic Sensors with Smart Hydrogel Patterned Arrays Using Electronic Resistive Channel Sensing for Readout
There is a strong commercial need for inexpensive point-of-use sensors for monitoring disease biomarkers or environmental contaminants in drinking water. Point-of-use sensors that employ smart polymer hydrogels as recognition elements can be tailored to detect almost any target analyte, but often su...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318584/ https://www.ncbi.nlm.nih.gov/pubmed/30674860 http://dx.doi.org/10.3390/gels4040084 |
_version_ | 1783384909667106816 |
---|---|
author | Leu, Hsuan-Yu Farhoudi, Navid Reiche, Christopher F. Körner, Julia Mohanty, Swomitra Solzbacher, Florian Magda, Jules |
author_facet | Leu, Hsuan-Yu Farhoudi, Navid Reiche, Christopher F. Körner, Julia Mohanty, Swomitra Solzbacher, Florian Magda, Jules |
author_sort | Leu, Hsuan-Yu |
collection | PubMed |
description | There is a strong commercial need for inexpensive point-of-use sensors for monitoring disease biomarkers or environmental contaminants in drinking water. Point-of-use sensors that employ smart polymer hydrogels as recognition elements can be tailored to detect almost any target analyte, but often suffer from long response times. Hence, we describe here a fabrication process that can be used to manufacture low-cost point-of-use hydrogel-based microfluidics sensors with short response times. In this process, mask-templated UV photopolymerization is used to produce arrays of smart hydrogel pillars inside sub-millimeter channels located upon microfluidics devices. When these pillars contact aqueous solutions containing a target analyte, they swell or shrink, thereby changing the resistance of the microfluidic channel to ionic current flow when a small bias voltage is applied to the system. Hence resistance measurements can be used to transduce hydrogel swelling changes into electrical signals. The only instrumentation required is a simple portable potentiostat that can be operated using a smartphone or a laptop, thus making the system suitable for point of use. Rapid hydrogel response rate is achieved by fabricating arrays of smart hydrogels that have large surface area-to-volume ratios. |
format | Online Article Text |
id | pubmed-6318584 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63185842019-01-17 Low-Cost Microfluidic Sensors with Smart Hydrogel Patterned Arrays Using Electronic Resistive Channel Sensing for Readout Leu, Hsuan-Yu Farhoudi, Navid Reiche, Christopher F. Körner, Julia Mohanty, Swomitra Solzbacher, Florian Magda, Jules Gels Article There is a strong commercial need for inexpensive point-of-use sensors for monitoring disease biomarkers or environmental contaminants in drinking water. Point-of-use sensors that employ smart polymer hydrogels as recognition elements can be tailored to detect almost any target analyte, but often suffer from long response times. Hence, we describe here a fabrication process that can be used to manufacture low-cost point-of-use hydrogel-based microfluidics sensors with short response times. In this process, mask-templated UV photopolymerization is used to produce arrays of smart hydrogel pillars inside sub-millimeter channels located upon microfluidics devices. When these pillars contact aqueous solutions containing a target analyte, they swell or shrink, thereby changing the resistance of the microfluidic channel to ionic current flow when a small bias voltage is applied to the system. Hence resistance measurements can be used to transduce hydrogel swelling changes into electrical signals. The only instrumentation required is a simple portable potentiostat that can be operated using a smartphone or a laptop, thus making the system suitable for point of use. Rapid hydrogel response rate is achieved by fabricating arrays of smart hydrogels that have large surface area-to-volume ratios. MDPI 2018-10-19 /pmc/articles/PMC6318584/ /pubmed/30674860 http://dx.doi.org/10.3390/gels4040084 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Leu, Hsuan-Yu Farhoudi, Navid Reiche, Christopher F. Körner, Julia Mohanty, Swomitra Solzbacher, Florian Magda, Jules Low-Cost Microfluidic Sensors with Smart Hydrogel Patterned Arrays Using Electronic Resistive Channel Sensing for Readout |
title | Low-Cost Microfluidic Sensors with Smart Hydrogel Patterned Arrays Using Electronic Resistive Channel Sensing for Readout |
title_full | Low-Cost Microfluidic Sensors with Smart Hydrogel Patterned Arrays Using Electronic Resistive Channel Sensing for Readout |
title_fullStr | Low-Cost Microfluidic Sensors with Smart Hydrogel Patterned Arrays Using Electronic Resistive Channel Sensing for Readout |
title_full_unstemmed | Low-Cost Microfluidic Sensors with Smart Hydrogel Patterned Arrays Using Electronic Resistive Channel Sensing for Readout |
title_short | Low-Cost Microfluidic Sensors with Smart Hydrogel Patterned Arrays Using Electronic Resistive Channel Sensing for Readout |
title_sort | low-cost microfluidic sensors with smart hydrogel patterned arrays using electronic resistive channel sensing for readout |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318584/ https://www.ncbi.nlm.nih.gov/pubmed/30674860 http://dx.doi.org/10.3390/gels4040084 |
work_keys_str_mv | AT leuhsuanyu lowcostmicrofluidicsensorswithsmarthydrogelpatternedarraysusingelectronicresistivechannelsensingforreadout AT farhoudinavid lowcostmicrofluidicsensorswithsmarthydrogelpatternedarraysusingelectronicresistivechannelsensingforreadout AT reichechristopherf lowcostmicrofluidicsensorswithsmarthydrogelpatternedarraysusingelectronicresistivechannelsensingforreadout AT kornerjulia lowcostmicrofluidicsensorswithsmarthydrogelpatternedarraysusingelectronicresistivechannelsensingforreadout AT mohantyswomitra lowcostmicrofluidicsensorswithsmarthydrogelpatternedarraysusingelectronicresistivechannelsensingforreadout AT solzbacherflorian lowcostmicrofluidicsensorswithsmarthydrogelpatternedarraysusingelectronicresistivechannelsensingforreadout AT magdajules lowcostmicrofluidicsensorswithsmarthydrogelpatternedarraysusingelectronicresistivechannelsensingforreadout |