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Low-Cost Microfluidic Sensors with Smart Hydrogel Patterned Arrays Using Electronic Resistive Channel Sensing for Readout

There is a strong commercial need for inexpensive point-of-use sensors for monitoring disease biomarkers or environmental contaminants in drinking water. Point-of-use sensors that employ smart polymer hydrogels as recognition elements can be tailored to detect almost any target analyte, but often su...

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Autores principales: Leu, Hsuan-Yu, Farhoudi, Navid, Reiche, Christopher F., Körner, Julia, Mohanty, Swomitra, Solzbacher, Florian, Magda, Jules
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318584/
https://www.ncbi.nlm.nih.gov/pubmed/30674860
http://dx.doi.org/10.3390/gels4040084
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author Leu, Hsuan-Yu
Farhoudi, Navid
Reiche, Christopher F.
Körner, Julia
Mohanty, Swomitra
Solzbacher, Florian
Magda, Jules
author_facet Leu, Hsuan-Yu
Farhoudi, Navid
Reiche, Christopher F.
Körner, Julia
Mohanty, Swomitra
Solzbacher, Florian
Magda, Jules
author_sort Leu, Hsuan-Yu
collection PubMed
description There is a strong commercial need for inexpensive point-of-use sensors for monitoring disease biomarkers or environmental contaminants in drinking water. Point-of-use sensors that employ smart polymer hydrogels as recognition elements can be tailored to detect almost any target analyte, but often suffer from long response times. Hence, we describe here a fabrication process that can be used to manufacture low-cost point-of-use hydrogel-based microfluidics sensors with short response times. In this process, mask-templated UV photopolymerization is used to produce arrays of smart hydrogel pillars inside sub-millimeter channels located upon microfluidics devices. When these pillars contact aqueous solutions containing a target analyte, they swell or shrink, thereby changing the resistance of the microfluidic channel to ionic current flow when a small bias voltage is applied to the system. Hence resistance measurements can be used to transduce hydrogel swelling changes into electrical signals. The only instrumentation required is a simple portable potentiostat that can be operated using a smartphone or a laptop, thus making the system suitable for point of use. Rapid hydrogel response rate is achieved by fabricating arrays of smart hydrogels that have large surface area-to-volume ratios.
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spelling pubmed-63185842019-01-17 Low-Cost Microfluidic Sensors with Smart Hydrogel Patterned Arrays Using Electronic Resistive Channel Sensing for Readout Leu, Hsuan-Yu Farhoudi, Navid Reiche, Christopher F. Körner, Julia Mohanty, Swomitra Solzbacher, Florian Magda, Jules Gels Article There is a strong commercial need for inexpensive point-of-use sensors for monitoring disease biomarkers or environmental contaminants in drinking water. Point-of-use sensors that employ smart polymer hydrogels as recognition elements can be tailored to detect almost any target analyte, but often suffer from long response times. Hence, we describe here a fabrication process that can be used to manufacture low-cost point-of-use hydrogel-based microfluidics sensors with short response times. In this process, mask-templated UV photopolymerization is used to produce arrays of smart hydrogel pillars inside sub-millimeter channels located upon microfluidics devices. When these pillars contact aqueous solutions containing a target analyte, they swell or shrink, thereby changing the resistance of the microfluidic channel to ionic current flow when a small bias voltage is applied to the system. Hence resistance measurements can be used to transduce hydrogel swelling changes into electrical signals. The only instrumentation required is a simple portable potentiostat that can be operated using a smartphone or a laptop, thus making the system suitable for point of use. Rapid hydrogel response rate is achieved by fabricating arrays of smart hydrogels that have large surface area-to-volume ratios. MDPI 2018-10-19 /pmc/articles/PMC6318584/ /pubmed/30674860 http://dx.doi.org/10.3390/gels4040084 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Leu, Hsuan-Yu
Farhoudi, Navid
Reiche, Christopher F.
Körner, Julia
Mohanty, Swomitra
Solzbacher, Florian
Magda, Jules
Low-Cost Microfluidic Sensors with Smart Hydrogel Patterned Arrays Using Electronic Resistive Channel Sensing for Readout
title Low-Cost Microfluidic Sensors with Smart Hydrogel Patterned Arrays Using Electronic Resistive Channel Sensing for Readout
title_full Low-Cost Microfluidic Sensors with Smart Hydrogel Patterned Arrays Using Electronic Resistive Channel Sensing for Readout
title_fullStr Low-Cost Microfluidic Sensors with Smart Hydrogel Patterned Arrays Using Electronic Resistive Channel Sensing for Readout
title_full_unstemmed Low-Cost Microfluidic Sensors with Smart Hydrogel Patterned Arrays Using Electronic Resistive Channel Sensing for Readout
title_short Low-Cost Microfluidic Sensors with Smart Hydrogel Patterned Arrays Using Electronic Resistive Channel Sensing for Readout
title_sort low-cost microfluidic sensors with smart hydrogel patterned arrays using electronic resistive channel sensing for readout
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318584/
https://www.ncbi.nlm.nih.gov/pubmed/30674860
http://dx.doi.org/10.3390/gels4040084
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