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Assembly of a Tripeptide and Anti-Inflammatory Drugs into Supramolecular Hydrogels for Sustained Release
Supramolecular hydrogels offer interesting opportunities for co-assembly with drugs towards sustained release over time, which could be achieved given that the drug participates in the hydrogel nanostructure, and it is not simply physically entrapped within the gel matrix. (d)Leu-Phe-Phe is an attra...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318665/ https://www.ncbi.nlm.nih.gov/pubmed/30920525 http://dx.doi.org/10.3390/gels3030029 |
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author | Kurbasic, Marina Romano, Chiara D. Garcia, Ana M. Kralj, Slavko Marchesan, Silvia |
author_facet | Kurbasic, Marina Romano, Chiara D. Garcia, Ana M. Kralj, Slavko Marchesan, Silvia |
author_sort | Kurbasic, Marina |
collection | PubMed |
description | Supramolecular hydrogels offer interesting opportunities for co-assembly with drugs towards sustained release over time, which could be achieved given that the drug participates in the hydrogel nanostructure, and it is not simply physically entrapped within the gel matrix. (d)Leu-Phe-Phe is an attractive building block of biomaterials in light of the peptide’s inherent biocompatibility and biodegradability. This study evaluates the assembly of the tripeptide in the presence of either of the anti-inflammatory drugs ketoprofen or naproxen at levels analogous to commercial gel formulations. Fourier-transformed infrared (FT-IR), circular dichroism, Thioflavin T fluorescence, transmission electron microscopy (TEM), and oscillatory rheometry are used. Drug release over time is monitored by means of reverse-phase high performance liquid chromatography, and shows different kinetics for the two drugs. |
format | Online Article Text |
id | pubmed-6318665 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63186652019-01-17 Assembly of a Tripeptide and Anti-Inflammatory Drugs into Supramolecular Hydrogels for Sustained Release Kurbasic, Marina Romano, Chiara D. Garcia, Ana M. Kralj, Slavko Marchesan, Silvia Gels Article Supramolecular hydrogels offer interesting opportunities for co-assembly with drugs towards sustained release over time, which could be achieved given that the drug participates in the hydrogel nanostructure, and it is not simply physically entrapped within the gel matrix. (d)Leu-Phe-Phe is an attractive building block of biomaterials in light of the peptide’s inherent biocompatibility and biodegradability. This study evaluates the assembly of the tripeptide in the presence of either of the anti-inflammatory drugs ketoprofen or naproxen at levels analogous to commercial gel formulations. Fourier-transformed infrared (FT-IR), circular dichroism, Thioflavin T fluorescence, transmission electron microscopy (TEM), and oscillatory rheometry are used. Drug release over time is monitored by means of reverse-phase high performance liquid chromatography, and shows different kinetics for the two drugs. MDPI 2017-08-03 /pmc/articles/PMC6318665/ /pubmed/30920525 http://dx.doi.org/10.3390/gels3030029 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kurbasic, Marina Romano, Chiara D. Garcia, Ana M. Kralj, Slavko Marchesan, Silvia Assembly of a Tripeptide and Anti-Inflammatory Drugs into Supramolecular Hydrogels for Sustained Release |
title | Assembly of a Tripeptide and Anti-Inflammatory Drugs into Supramolecular Hydrogels for Sustained Release |
title_full | Assembly of a Tripeptide and Anti-Inflammatory Drugs into Supramolecular Hydrogels for Sustained Release |
title_fullStr | Assembly of a Tripeptide and Anti-Inflammatory Drugs into Supramolecular Hydrogels for Sustained Release |
title_full_unstemmed | Assembly of a Tripeptide and Anti-Inflammatory Drugs into Supramolecular Hydrogels for Sustained Release |
title_short | Assembly of a Tripeptide and Anti-Inflammatory Drugs into Supramolecular Hydrogels for Sustained Release |
title_sort | assembly of a tripeptide and anti-inflammatory drugs into supramolecular hydrogels for sustained release |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318665/ https://www.ncbi.nlm.nih.gov/pubmed/30920525 http://dx.doi.org/10.3390/gels3030029 |
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