Peptide Drug Release Behavior from Biodegradable Temperature-Responsive Injectable Hydrogels Exhibiting Irreversible Gelation

We investigated the release behavior of glucagon-like peptide-1 (GLP-1) from a biodegradable injectable polymer (IP) hydrogel. This hydrogel shows temperature-responsive irreversible gelation due to the covalent bond formation through a thiol-ene reaction. In vitro sustained release of GLP-1 from an...

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Autores principales: Takata, Kazuyuki, Takai, Hiroki, Yoshizaki, Yuta, Nagata, Takuya, Kawahara, Keisuke, Yoshida, Yasuyuki, Kuzuya, Akinori, Ohya, Yuichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318690/
https://www.ncbi.nlm.nih.gov/pubmed/30920533
http://dx.doi.org/10.3390/gels3040038
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author Takata, Kazuyuki
Takai, Hiroki
Yoshizaki, Yuta
Nagata, Takuya
Kawahara, Keisuke
Yoshida, Yasuyuki
Kuzuya, Akinori
Ohya, Yuichi
author_facet Takata, Kazuyuki
Takai, Hiroki
Yoshizaki, Yuta
Nagata, Takuya
Kawahara, Keisuke
Yoshida, Yasuyuki
Kuzuya, Akinori
Ohya, Yuichi
author_sort Takata, Kazuyuki
collection PubMed
description We investigated the release behavior of glucagon-like peptide-1 (GLP-1) from a biodegradable injectable polymer (IP) hydrogel. This hydrogel shows temperature-responsive irreversible gelation due to the covalent bond formation through a thiol-ene reaction. In vitro sustained release of GLP-1 from an irreversible IP formulation (F(P1/D+PA(40))) was observed compared with a reversible (physical gelation) IP formulation (F(P1)). Moreover, pharmaceutically active levels of GLP-1 were maintained in blood after subcutaneous injection of the irreversible IP formulation into rats. This system should be useful for the minimally invasive sustained drug release of peptide drugs and other water-soluble bioactive reagents.
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spelling pubmed-63186902019-01-17 Peptide Drug Release Behavior from Biodegradable Temperature-Responsive Injectable Hydrogels Exhibiting Irreversible Gelation Takata, Kazuyuki Takai, Hiroki Yoshizaki, Yuta Nagata, Takuya Kawahara, Keisuke Yoshida, Yasuyuki Kuzuya, Akinori Ohya, Yuichi Gels Article We investigated the release behavior of glucagon-like peptide-1 (GLP-1) from a biodegradable injectable polymer (IP) hydrogel. This hydrogel shows temperature-responsive irreversible gelation due to the covalent bond formation through a thiol-ene reaction. In vitro sustained release of GLP-1 from an irreversible IP formulation (F(P1/D+PA(40))) was observed compared with a reversible (physical gelation) IP formulation (F(P1)). Moreover, pharmaceutically active levels of GLP-1 were maintained in blood after subcutaneous injection of the irreversible IP formulation into rats. This system should be useful for the minimally invasive sustained drug release of peptide drugs and other water-soluble bioactive reagents. MDPI 2017-10-15 /pmc/articles/PMC6318690/ /pubmed/30920533 http://dx.doi.org/10.3390/gels3040038 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Takata, Kazuyuki
Takai, Hiroki
Yoshizaki, Yuta
Nagata, Takuya
Kawahara, Keisuke
Yoshida, Yasuyuki
Kuzuya, Akinori
Ohya, Yuichi
Peptide Drug Release Behavior from Biodegradable Temperature-Responsive Injectable Hydrogels Exhibiting Irreversible Gelation
title Peptide Drug Release Behavior from Biodegradable Temperature-Responsive Injectable Hydrogels Exhibiting Irreversible Gelation
title_full Peptide Drug Release Behavior from Biodegradable Temperature-Responsive Injectable Hydrogels Exhibiting Irreversible Gelation
title_fullStr Peptide Drug Release Behavior from Biodegradable Temperature-Responsive Injectable Hydrogels Exhibiting Irreversible Gelation
title_full_unstemmed Peptide Drug Release Behavior from Biodegradable Temperature-Responsive Injectable Hydrogels Exhibiting Irreversible Gelation
title_short Peptide Drug Release Behavior from Biodegradable Temperature-Responsive Injectable Hydrogels Exhibiting Irreversible Gelation
title_sort peptide drug release behavior from biodegradable temperature-responsive injectable hydrogels exhibiting irreversible gelation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318690/
https://www.ncbi.nlm.nih.gov/pubmed/30920533
http://dx.doi.org/10.3390/gels3040038
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