Design of Hybrid Gels Based on Gellan-Cholesterol Derivative and P90G Liposomes for Drug Depot Applications

Gels are extensively studied in the drug delivery field because of their potential benefits in therapeutics. Depot gel systems fall in this area, and the interest in their development has been focused on long-lasting, biocompatible, and resorbable delivery devices. The present work describes a new c...

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Autores principales: Zoratto, Nicole, Palmieri, Francesca Romana, Cencetti, Claudia, Montanari, Elita, Di Meo, Chiara, Manca, Maria Letizia, Manconi, Maria, Matricardi, Pietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318693/
https://www.ncbi.nlm.nih.gov/pubmed/30920514
http://dx.doi.org/10.3390/gels3020018
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author Zoratto, Nicole
Palmieri, Francesca Romana
Cencetti, Claudia
Montanari, Elita
Di Meo, Chiara
Manca, Maria Letizia
Manconi, Maria
Matricardi, Pietro
author_facet Zoratto, Nicole
Palmieri, Francesca Romana
Cencetti, Claudia
Montanari, Elita
Di Meo, Chiara
Manca, Maria Letizia
Manconi, Maria
Matricardi, Pietro
author_sort Zoratto, Nicole
collection PubMed
description Gels are extensively studied in the drug delivery field because of their potential benefits in therapeutics. Depot gel systems fall in this area, and the interest in their development has been focused on long-lasting, biocompatible, and resorbable delivery devices. The present work describes a new class of hybrid gels that stem from the interaction between liposomes based on P90G phospholipid and the cholesterol derivative of the polysaccharide gellan. The mechanical properties of these gels and the delivery profiles of the anti-inflammatory model drug diclofenac embedded in such systems confirmed the suitability of these hybrid gels as a good candidate for drug depot applications.
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spelling pubmed-63186932019-01-17 Design of Hybrid Gels Based on Gellan-Cholesterol Derivative and P90G Liposomes for Drug Depot Applications Zoratto, Nicole Palmieri, Francesca Romana Cencetti, Claudia Montanari, Elita Di Meo, Chiara Manca, Maria Letizia Manconi, Maria Matricardi, Pietro Gels Article Gels are extensively studied in the drug delivery field because of their potential benefits in therapeutics. Depot gel systems fall in this area, and the interest in their development has been focused on long-lasting, biocompatible, and resorbable delivery devices. The present work describes a new class of hybrid gels that stem from the interaction between liposomes based on P90G phospholipid and the cholesterol derivative of the polysaccharide gellan. The mechanical properties of these gels and the delivery profiles of the anti-inflammatory model drug diclofenac embedded in such systems confirmed the suitability of these hybrid gels as a good candidate for drug depot applications. MDPI 2017-05-08 /pmc/articles/PMC6318693/ /pubmed/30920514 http://dx.doi.org/10.3390/gels3020018 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zoratto, Nicole
Palmieri, Francesca Romana
Cencetti, Claudia
Montanari, Elita
Di Meo, Chiara
Manca, Maria Letizia
Manconi, Maria
Matricardi, Pietro
Design of Hybrid Gels Based on Gellan-Cholesterol Derivative and P90G Liposomes for Drug Depot Applications
title Design of Hybrid Gels Based on Gellan-Cholesterol Derivative and P90G Liposomes for Drug Depot Applications
title_full Design of Hybrid Gels Based on Gellan-Cholesterol Derivative and P90G Liposomes for Drug Depot Applications
title_fullStr Design of Hybrid Gels Based on Gellan-Cholesterol Derivative and P90G Liposomes for Drug Depot Applications
title_full_unstemmed Design of Hybrid Gels Based on Gellan-Cholesterol Derivative and P90G Liposomes for Drug Depot Applications
title_short Design of Hybrid Gels Based on Gellan-Cholesterol Derivative and P90G Liposomes for Drug Depot Applications
title_sort design of hybrid gels based on gellan-cholesterol derivative and p90g liposomes for drug depot applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318693/
https://www.ncbi.nlm.nih.gov/pubmed/30920514
http://dx.doi.org/10.3390/gels3020018
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