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New Insights in Bladder Cancer Diagnosis: Urinary miRNAs and Proteins

Bladder cancer is the 10th-most common cancer worldwide. The diagnosis and follow-up of patients require costly invasive methods and due to these expenses, bladder cancer continues to be one of the expensive malignancies. Early diagnosis is crucial in bladder cancer as it is in other cancers; theref...

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Autores principales: Güllü Amuran, Gökçe, Peker Eyuboglu, Irem, Tinay, Ilker, Akkiprik, Mustafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318758/
https://www.ncbi.nlm.nih.gov/pubmed/30544619
http://dx.doi.org/10.3390/medsci6040113
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author Güllü Amuran, Gökçe
Peker Eyuboglu, Irem
Tinay, Ilker
Akkiprik, Mustafa
author_facet Güllü Amuran, Gökçe
Peker Eyuboglu, Irem
Tinay, Ilker
Akkiprik, Mustafa
author_sort Güllü Amuran, Gökçe
collection PubMed
description Bladder cancer is the 10th-most common cancer worldwide. The diagnosis and follow-up of patients require costly invasive methods and due to these expenses, bladder cancer continues to be one of the expensive malignancies. Early diagnosis is crucial in bladder cancer as it is in other cancers; therefore, non-invasive biomarkers for early diagnosis are very important. In this review, we aimed to focus on the most recent investigations on potential urinary micro RNA (miRNA) and protein biomarkers for bladder cancer diagnosis and their associated pathways. Studies performed by different groups were compiled and the biomarker properties of various proteins and miRNAs in the urine of bladder cancer patients were evaluated. Key studies were obtained by searching keywords “bladder cancer, urinary miRNA, urinary protein, urinary biomarker”. Targets and the pathways of the miRNAs and proteins were analyzed according to mirBase Catalogue and Panther Database. The major pathways that are targeted by aberrantly expressed miRNAs are Cholecystokinin receptor (CCKR), p53, Wnt signaling pathway, and feedback loops. We hereby conclude that urinary micro RNAs and proteins are promising candidates for bladder cancer diagnosis. It should be noted that urine collection, storage conditions, choice of fraction, and normalization strategies should be standardized.
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spelling pubmed-63187582019-01-04 New Insights in Bladder Cancer Diagnosis: Urinary miRNAs and Proteins Güllü Amuran, Gökçe Peker Eyuboglu, Irem Tinay, Ilker Akkiprik, Mustafa Med Sci (Basel) Review Bladder cancer is the 10th-most common cancer worldwide. The diagnosis and follow-up of patients require costly invasive methods and due to these expenses, bladder cancer continues to be one of the expensive malignancies. Early diagnosis is crucial in bladder cancer as it is in other cancers; therefore, non-invasive biomarkers for early diagnosis are very important. In this review, we aimed to focus on the most recent investigations on potential urinary micro RNA (miRNA) and protein biomarkers for bladder cancer diagnosis and their associated pathways. Studies performed by different groups were compiled and the biomarker properties of various proteins and miRNAs in the urine of bladder cancer patients were evaluated. Key studies were obtained by searching keywords “bladder cancer, urinary miRNA, urinary protein, urinary biomarker”. Targets and the pathways of the miRNAs and proteins were analyzed according to mirBase Catalogue and Panther Database. The major pathways that are targeted by aberrantly expressed miRNAs are Cholecystokinin receptor (CCKR), p53, Wnt signaling pathway, and feedback loops. We hereby conclude that urinary micro RNAs and proteins are promising candidates for bladder cancer diagnosis. It should be noted that urine collection, storage conditions, choice of fraction, and normalization strategies should be standardized. MDPI 2018-12-07 /pmc/articles/PMC6318758/ /pubmed/30544619 http://dx.doi.org/10.3390/medsci6040113 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Güllü Amuran, Gökçe
Peker Eyuboglu, Irem
Tinay, Ilker
Akkiprik, Mustafa
New Insights in Bladder Cancer Diagnosis: Urinary miRNAs and Proteins
title New Insights in Bladder Cancer Diagnosis: Urinary miRNAs and Proteins
title_full New Insights in Bladder Cancer Diagnosis: Urinary miRNAs and Proteins
title_fullStr New Insights in Bladder Cancer Diagnosis: Urinary miRNAs and Proteins
title_full_unstemmed New Insights in Bladder Cancer Diagnosis: Urinary miRNAs and Proteins
title_short New Insights in Bladder Cancer Diagnosis: Urinary miRNAs and Proteins
title_sort new insights in bladder cancer diagnosis: urinary mirnas and proteins
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318758/
https://www.ncbi.nlm.nih.gov/pubmed/30544619
http://dx.doi.org/10.3390/medsci6040113
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