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New Insights in Bladder Cancer Diagnosis: Urinary miRNAs and Proteins
Bladder cancer is the 10th-most common cancer worldwide. The diagnosis and follow-up of patients require costly invasive methods and due to these expenses, bladder cancer continues to be one of the expensive malignancies. Early diagnosis is crucial in bladder cancer as it is in other cancers; theref...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318758/ https://www.ncbi.nlm.nih.gov/pubmed/30544619 http://dx.doi.org/10.3390/medsci6040113 |
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author | Güllü Amuran, Gökçe Peker Eyuboglu, Irem Tinay, Ilker Akkiprik, Mustafa |
author_facet | Güllü Amuran, Gökçe Peker Eyuboglu, Irem Tinay, Ilker Akkiprik, Mustafa |
author_sort | Güllü Amuran, Gökçe |
collection | PubMed |
description | Bladder cancer is the 10th-most common cancer worldwide. The diagnosis and follow-up of patients require costly invasive methods and due to these expenses, bladder cancer continues to be one of the expensive malignancies. Early diagnosis is crucial in bladder cancer as it is in other cancers; therefore, non-invasive biomarkers for early diagnosis are very important. In this review, we aimed to focus on the most recent investigations on potential urinary micro RNA (miRNA) and protein biomarkers for bladder cancer diagnosis and their associated pathways. Studies performed by different groups were compiled and the biomarker properties of various proteins and miRNAs in the urine of bladder cancer patients were evaluated. Key studies were obtained by searching keywords “bladder cancer, urinary miRNA, urinary protein, urinary biomarker”. Targets and the pathways of the miRNAs and proteins were analyzed according to mirBase Catalogue and Panther Database. The major pathways that are targeted by aberrantly expressed miRNAs are Cholecystokinin receptor (CCKR), p53, Wnt signaling pathway, and feedback loops. We hereby conclude that urinary micro RNAs and proteins are promising candidates for bladder cancer diagnosis. It should be noted that urine collection, storage conditions, choice of fraction, and normalization strategies should be standardized. |
format | Online Article Text |
id | pubmed-6318758 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63187582019-01-04 New Insights in Bladder Cancer Diagnosis: Urinary miRNAs and Proteins Güllü Amuran, Gökçe Peker Eyuboglu, Irem Tinay, Ilker Akkiprik, Mustafa Med Sci (Basel) Review Bladder cancer is the 10th-most common cancer worldwide. The diagnosis and follow-up of patients require costly invasive methods and due to these expenses, bladder cancer continues to be one of the expensive malignancies. Early diagnosis is crucial in bladder cancer as it is in other cancers; therefore, non-invasive biomarkers for early diagnosis are very important. In this review, we aimed to focus on the most recent investigations on potential urinary micro RNA (miRNA) and protein biomarkers for bladder cancer diagnosis and their associated pathways. Studies performed by different groups were compiled and the biomarker properties of various proteins and miRNAs in the urine of bladder cancer patients were evaluated. Key studies were obtained by searching keywords “bladder cancer, urinary miRNA, urinary protein, urinary biomarker”. Targets and the pathways of the miRNAs and proteins were analyzed according to mirBase Catalogue and Panther Database. The major pathways that are targeted by aberrantly expressed miRNAs are Cholecystokinin receptor (CCKR), p53, Wnt signaling pathway, and feedback loops. We hereby conclude that urinary micro RNAs and proteins are promising candidates for bladder cancer diagnosis. It should be noted that urine collection, storage conditions, choice of fraction, and normalization strategies should be standardized. MDPI 2018-12-07 /pmc/articles/PMC6318758/ /pubmed/30544619 http://dx.doi.org/10.3390/medsci6040113 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Güllü Amuran, Gökçe Peker Eyuboglu, Irem Tinay, Ilker Akkiprik, Mustafa New Insights in Bladder Cancer Diagnosis: Urinary miRNAs and Proteins |
title | New Insights in Bladder Cancer Diagnosis: Urinary miRNAs and Proteins |
title_full | New Insights in Bladder Cancer Diagnosis: Urinary miRNAs and Proteins |
title_fullStr | New Insights in Bladder Cancer Diagnosis: Urinary miRNAs and Proteins |
title_full_unstemmed | New Insights in Bladder Cancer Diagnosis: Urinary miRNAs and Proteins |
title_short | New Insights in Bladder Cancer Diagnosis: Urinary miRNAs and Proteins |
title_sort | new insights in bladder cancer diagnosis: urinary mirnas and proteins |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318758/ https://www.ncbi.nlm.nih.gov/pubmed/30544619 http://dx.doi.org/10.3390/medsci6040113 |
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