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Plasticity of vagal afferent signaling in the gut
Vagal sensory neurons mediate the vago-vagal reflex which, in turn, regulates a wide array of gastrointestinal functions including esophageal motility, gastric accommodation and pancreatic enzyme secretion. These neurons also transmit sensory information from the gut to the central nervous system, w...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318799/ https://www.ncbi.nlm.nih.gov/pubmed/28454890 http://dx.doi.org/10.1016/j.medici.2017.03.002 |
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author | Grabauskas, Gintautas Owyang, Chung |
author_facet | Grabauskas, Gintautas Owyang, Chung |
author_sort | Grabauskas, Gintautas |
collection | PubMed |
description | Vagal sensory neurons mediate the vago-vagal reflex which, in turn, regulates a wide array of gastrointestinal functions including esophageal motility, gastric accommodation and pancreatic enzyme secretion. These neurons also transmit sensory information from the gut to the central nervous system, which then mediates the sensations of nausea, fullness and satiety. Recent research indicates that vagal afferent neurons process non-uniform properties and a significant degree of plasticity. These properties are important to ensure that vagally regulated gastrointestinal functions respond rapidly and appropriately to various intrinsic and extrinsic factors. Similar plastic changes in the vagus also occur in pathophysiological conditions, such as obesity and diabetes, resulting in abnormal gastrointestinal functions. A clear understanding of the mechanisms which mediate these events may provide novel therapeutic targets for the treatment of gastrointestinal disorders due to vago-vagal pathway malfunctions. |
format | Online Article Text |
id | pubmed-6318799 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
record_format | MEDLINE/PubMed |
spelling | pubmed-63187992019-01-04 Plasticity of vagal afferent signaling in the gut Grabauskas, Gintautas Owyang, Chung Medicina (Kaunas) Article Vagal sensory neurons mediate the vago-vagal reflex which, in turn, regulates a wide array of gastrointestinal functions including esophageal motility, gastric accommodation and pancreatic enzyme secretion. These neurons also transmit sensory information from the gut to the central nervous system, which then mediates the sensations of nausea, fullness and satiety. Recent research indicates that vagal afferent neurons process non-uniform properties and a significant degree of plasticity. These properties are important to ensure that vagally regulated gastrointestinal functions respond rapidly and appropriately to various intrinsic and extrinsic factors. Similar plastic changes in the vagus also occur in pathophysiological conditions, such as obesity and diabetes, resulting in abnormal gastrointestinal functions. A clear understanding of the mechanisms which mediate these events may provide novel therapeutic targets for the treatment of gastrointestinal disorders due to vago-vagal pathway malfunctions. 2017-04-10 2017 /pmc/articles/PMC6318799/ /pubmed/28454890 http://dx.doi.org/10.1016/j.medici.2017.03.002 Text en This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Article Grabauskas, Gintautas Owyang, Chung Plasticity of vagal afferent signaling in the gut |
title | Plasticity of vagal afferent signaling in the gut |
title_full | Plasticity of vagal afferent signaling in the gut |
title_fullStr | Plasticity of vagal afferent signaling in the gut |
title_full_unstemmed | Plasticity of vagal afferent signaling in the gut |
title_short | Plasticity of vagal afferent signaling in the gut |
title_sort | plasticity of vagal afferent signaling in the gut |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318799/ https://www.ncbi.nlm.nih.gov/pubmed/28454890 http://dx.doi.org/10.1016/j.medici.2017.03.002 |
work_keys_str_mv | AT grabauskasgintautas plasticityofvagalafferentsignalinginthegut AT owyangchung plasticityofvagalafferentsignalinginthegut |