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Plasticity of vagal afferent signaling in the gut

Vagal sensory neurons mediate the vago-vagal reflex which, in turn, regulates a wide array of gastrointestinal functions including esophageal motility, gastric accommodation and pancreatic enzyme secretion. These neurons also transmit sensory information from the gut to the central nervous system, w...

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Detalles Bibliográficos
Autores principales: Grabauskas, Gintautas, Owyang, Chung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318799/
https://www.ncbi.nlm.nih.gov/pubmed/28454890
http://dx.doi.org/10.1016/j.medici.2017.03.002
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author Grabauskas, Gintautas
Owyang, Chung
author_facet Grabauskas, Gintautas
Owyang, Chung
author_sort Grabauskas, Gintautas
collection PubMed
description Vagal sensory neurons mediate the vago-vagal reflex which, in turn, regulates a wide array of gastrointestinal functions including esophageal motility, gastric accommodation and pancreatic enzyme secretion. These neurons also transmit sensory information from the gut to the central nervous system, which then mediates the sensations of nausea, fullness and satiety. Recent research indicates that vagal afferent neurons process non-uniform properties and a significant degree of plasticity. These properties are important to ensure that vagally regulated gastrointestinal functions respond rapidly and appropriately to various intrinsic and extrinsic factors. Similar plastic changes in the vagus also occur in pathophysiological conditions, such as obesity and diabetes, resulting in abnormal gastrointestinal functions. A clear understanding of the mechanisms which mediate these events may provide novel therapeutic targets for the treatment of gastrointestinal disorders due to vago-vagal pathway malfunctions.
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spelling pubmed-63187992019-01-04 Plasticity of vagal afferent signaling in the gut Grabauskas, Gintautas Owyang, Chung Medicina (Kaunas) Article Vagal sensory neurons mediate the vago-vagal reflex which, in turn, regulates a wide array of gastrointestinal functions including esophageal motility, gastric accommodation and pancreatic enzyme secretion. These neurons also transmit sensory information from the gut to the central nervous system, which then mediates the sensations of nausea, fullness and satiety. Recent research indicates that vagal afferent neurons process non-uniform properties and a significant degree of plasticity. These properties are important to ensure that vagally regulated gastrointestinal functions respond rapidly and appropriately to various intrinsic and extrinsic factors. Similar plastic changes in the vagus also occur in pathophysiological conditions, such as obesity and diabetes, resulting in abnormal gastrointestinal functions. A clear understanding of the mechanisms which mediate these events may provide novel therapeutic targets for the treatment of gastrointestinal disorders due to vago-vagal pathway malfunctions. 2017-04-10 2017 /pmc/articles/PMC6318799/ /pubmed/28454890 http://dx.doi.org/10.1016/j.medici.2017.03.002 Text en This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Article
Grabauskas, Gintautas
Owyang, Chung
Plasticity of vagal afferent signaling in the gut
title Plasticity of vagal afferent signaling in the gut
title_full Plasticity of vagal afferent signaling in the gut
title_fullStr Plasticity of vagal afferent signaling in the gut
title_full_unstemmed Plasticity of vagal afferent signaling in the gut
title_short Plasticity of vagal afferent signaling in the gut
title_sort plasticity of vagal afferent signaling in the gut
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318799/
https://www.ncbi.nlm.nih.gov/pubmed/28454890
http://dx.doi.org/10.1016/j.medici.2017.03.002
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