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Release of silicone oil droplets from syringes

BACKGROUND: Intravitreal silicone oil droplets have been found in the vitreous. The aim of this study is to compare the rates of silicone oil released by different brands of commonly used syringes for intravitreal injection after agitation by flicking. METHODS: Three models of two brands of syringes...

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Autores principales: Melo, Gustavo Barreto, Dias Junior, Celso de Souza, Carvalho, Mariana Reis, Cardoso, Alexandre Lima, Morais, Fábio Barreto, Figueira, Ana Carolina Migliorini, Lima Filho, Acácio Alves Souza, Emerson, Geoffrey Guy, Maia, Maurício
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318836/
https://www.ncbi.nlm.nih.gov/pubmed/30788149
http://dx.doi.org/10.1186/s40942-018-0153-8
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author Melo, Gustavo Barreto
Dias Junior, Celso de Souza
Carvalho, Mariana Reis
Cardoso, Alexandre Lima
Morais, Fábio Barreto
Figueira, Ana Carolina Migliorini
Lima Filho, Acácio Alves Souza
Emerson, Geoffrey Guy
Maia, Maurício
author_facet Melo, Gustavo Barreto
Dias Junior, Celso de Souza
Carvalho, Mariana Reis
Cardoso, Alexandre Lima
Morais, Fábio Barreto
Figueira, Ana Carolina Migliorini
Lima Filho, Acácio Alves Souza
Emerson, Geoffrey Guy
Maia, Maurício
author_sort Melo, Gustavo Barreto
collection PubMed
description BACKGROUND: Intravitreal silicone oil droplets have been found in the vitreous. The aim of this study is to compare the rates of silicone oil released by different brands of commonly used syringes for intravitreal injection after agitation by flicking. METHODS: Three models of two brands of syringes were analyzed for their rates of silicone oil release: Saldanha Rodrigues (SR) 1 mL insulin syringe (SR, Brazil, syringe 1), Becton–Dickinson (BD) Plastipak 1 mL insulin syringe (Brazil, syringe 2), and BD Safety-Glide 1 mL insulin syringe (USA, syringe 3). All syringes were tested under four different conditions: positive control (fluid with addition of silicone oil) without agitation (group 1, n = 5); positive control with agitation (group 2, n = 3); fluid only without agitation (group 3, n = 5); and fluid only with agitation (group 4, n = 5). Masked graders performed all analyses using light microscopy. RESULTS: All syringes (1, 2, and 3) released silicone oil droplets in the positive control group regardless of the agitation status (groups 1 and 2). When no oil was added and the syringes were not agitated, only syringe 1 released silicone oil droplets (40% of samples). After agitation, syringes 1 and 3 released silicone oil droplets in all samples. Quantitative analysis showed a significantly (P = 0.011; 11.2 ± 2.9 vs. 0.6 ± 0.9, respectively) higher mean number of silicone oil droplets released by syringe 1 after agitation compared to no agitation. Syringe 1 also had significantly (P = 0.002, 11.2 ± 2.9 vs. 0.0 ± 0.0 vs. 2.2 ± 0.8, respectively) more droplets than syringes 2 and 3 after agitation. CONCLUSIONS: Syringes commonly used for intravitreal injections frequently release silicone oil droplets when agitated by flicking, especially the SR insulin ones. We recommend that they not be agitated at the time of intravitreal injection and that the manufacturers consider producing syringes adapted for intraocular use.
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spelling pubmed-63188362019-02-20 Release of silicone oil droplets from syringes Melo, Gustavo Barreto Dias Junior, Celso de Souza Carvalho, Mariana Reis Cardoso, Alexandre Lima Morais, Fábio Barreto Figueira, Ana Carolina Migliorini Lima Filho, Acácio Alves Souza Emerson, Geoffrey Guy Maia, Maurício Int J Retina Vitreous Original Article BACKGROUND: Intravitreal silicone oil droplets have been found in the vitreous. The aim of this study is to compare the rates of silicone oil released by different brands of commonly used syringes for intravitreal injection after agitation by flicking. METHODS: Three models of two brands of syringes were analyzed for their rates of silicone oil release: Saldanha Rodrigues (SR) 1 mL insulin syringe (SR, Brazil, syringe 1), Becton–Dickinson (BD) Plastipak 1 mL insulin syringe (Brazil, syringe 2), and BD Safety-Glide 1 mL insulin syringe (USA, syringe 3). All syringes were tested under four different conditions: positive control (fluid with addition of silicone oil) without agitation (group 1, n = 5); positive control with agitation (group 2, n = 3); fluid only without agitation (group 3, n = 5); and fluid only with agitation (group 4, n = 5). Masked graders performed all analyses using light microscopy. RESULTS: All syringes (1, 2, and 3) released silicone oil droplets in the positive control group regardless of the agitation status (groups 1 and 2). When no oil was added and the syringes were not agitated, only syringe 1 released silicone oil droplets (40% of samples). After agitation, syringes 1 and 3 released silicone oil droplets in all samples. Quantitative analysis showed a significantly (P = 0.011; 11.2 ± 2.9 vs. 0.6 ± 0.9, respectively) higher mean number of silicone oil droplets released by syringe 1 after agitation compared to no agitation. Syringe 1 also had significantly (P = 0.002, 11.2 ± 2.9 vs. 0.0 ± 0.0 vs. 2.2 ± 0.8, respectively) more droplets than syringes 2 and 3 after agitation. CONCLUSIONS: Syringes commonly used for intravitreal injections frequently release silicone oil droplets when agitated by flicking, especially the SR insulin ones. We recommend that they not be agitated at the time of intravitreal injection and that the manufacturers consider producing syringes adapted for intraocular use. BioMed Central 2019-01-03 /pmc/articles/PMC6318836/ /pubmed/30788149 http://dx.doi.org/10.1186/s40942-018-0153-8 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Original Article
Melo, Gustavo Barreto
Dias Junior, Celso de Souza
Carvalho, Mariana Reis
Cardoso, Alexandre Lima
Morais, Fábio Barreto
Figueira, Ana Carolina Migliorini
Lima Filho, Acácio Alves Souza
Emerson, Geoffrey Guy
Maia, Maurício
Release of silicone oil droplets from syringes
title Release of silicone oil droplets from syringes
title_full Release of silicone oil droplets from syringes
title_fullStr Release of silicone oil droplets from syringes
title_full_unstemmed Release of silicone oil droplets from syringes
title_short Release of silicone oil droplets from syringes
title_sort release of silicone oil droplets from syringes
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318836/
https://www.ncbi.nlm.nih.gov/pubmed/30788149
http://dx.doi.org/10.1186/s40942-018-0153-8
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