A pathogenic tau fragment compromises microtubules, disrupts insulin signaling and induces the unfolded protein response

Human tauopathies including Alzheimer’s disease, progressive supranuclear palsy and related disorders, are characterized by deposition of pathological forms of tau, synaptic dysfunction and neuronal loss. We have previously identified a pathogenic C-terminal tau fragment (Tau35) that is associated w...

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Detalles Bibliográficos
Autores principales: Guo, Tong, Dakkak, Dina, Rodriguez-Martin, Teresa, Noble, Wendy, Hanger, Diane P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318896/
https://www.ncbi.nlm.nih.gov/pubmed/30606258
http://dx.doi.org/10.1186/s40478-018-0651-9

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