TRAIL stabilization and cancer cell sensitization to its pro-apoptotic activity achieved through genetic fusion with arginine deiminase

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) binds to death receptors and induces apoptosis in various cancer cell lines while sparing normal cells. Recombinant TRAIL has shown good safety and efficacy profiles in preclinical cancer models. However, clinical success has been...

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Detalles Bibliográficos
Autores principales: Brin, Elena, Wu, Katherine, Dagostino, Eleanor, Meng-Chiang Kuo, Mario, He, Yudou, Shia, Wei-Jong, Chen, Li-Chang, Stempniak, Mariusz, Hickey, Richard, Almassy, Robert, Showalter, Richard, Thomson, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319333/
https://www.ncbi.nlm.nih.gov/pubmed/30651925
http://dx.doi.org/10.18632/oncotarget.26398

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