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Insight into the PTEN – p85α interaction and lipid binding properties of the p85α BH domain

The phosphatidylinositol 3-kinase (PI3K) pathway plays a key role in regulating cell growth and cell survival and is frequently deregulated in cancer cells. p85α regulates the p110α lipid kinase, and also stabilizes and stimulates PTEN, the lipid phosphatase that downregulates this pathway. In this...

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Detalles Bibliográficos
Autores principales:	Marshall, Jeremy D.S., Mellor, Paul, Ruan, Xuan, Whitecross, Dielle E., Moore, Stanley A., Anderson, Deborah H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319338/ https://www.ncbi.nlm.nih.gov/pubmed/30651929 http://dx.doi.org/10.18632/oncotarget.26432

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