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Effects of endurance training on hippocampus DJ‐1, cannabinoid receptor type 2 and blood glucose concentration in diabetic rats

AIMS/INTRODUCTION: To investigate the effect of endurance training on hippocampus DJ‐1 and cannabinoid receptor type 2 (CB (2)) protein and blood glucose concentration in diabetic rats. MATERIALS AND METHODS: A total of 32 rats were randomly divided into diabetic (D), diabetic and exercise (DE), exe...

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Detalles Bibliográficos
Autores principales: Kurd, Mohammad, Valipour Dehnou, Vahid, Tavakoli, Seyed A, Gahreman, Daniel E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319482/
https://www.ncbi.nlm.nih.gov/pubmed/29791076
http://dx.doi.org/10.1111/jdi.12868
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author Kurd, Mohammad
Valipour Dehnou, Vahid
Tavakoli, Seyed A
Gahreman, Daniel E
author_facet Kurd, Mohammad
Valipour Dehnou, Vahid
Tavakoli, Seyed A
Gahreman, Daniel E
author_sort Kurd, Mohammad
collection PubMed
description AIMS/INTRODUCTION: To investigate the effect of endurance training on hippocampus DJ‐1 and cannabinoid receptor type 2 (CB (2)) protein and blood glucose concentration in diabetic rats. MATERIALS AND METHODS: A total of 32 rats were randomly divided into diabetic (D), diabetic and exercise (DE), exercise (E) and control (C) groups. The endurance training was carried out five times per week for 6 weeks. The hippocampus DJ‐1 and CB (2) were measured using an enzyme‐linked immunosorbent assay method. RESULTS: The level of DJ‐1 in the D group was significantly higher than the other groups (P ≤ 0.01). However, the level of DJ‐1 was not significantly different between the C, E and DE groups. In addition, the level of CB (2) was significantly lower in the D group compared with the other groups (P ≤ 0.01). Blood glucose was significantly higher in the D group compared with the DE group (P ≤ 0.05). Furthermore, a significant positive correlation between the level of DJ‐1 and blood glucose was observed (r = 0.67, P ≤ 0.001). There was also a significant inverse correlation between the level of CB (2) and blood glucose (r = −0.77, P ≤ 0.001). CONCLUSIONS: The results of this study suggest that the level of DJ‐1 and CB (2) might change in response to diabetes, and regular aerobic exercise could mediate the effect of DJ‐1 and CB (2) on diabetes‐induced neurodegenerative diseases.
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spelling pubmed-63194822019-01-08 Effects of endurance training on hippocampus DJ‐1, cannabinoid receptor type 2 and blood glucose concentration in diabetic rats Kurd, Mohammad Valipour Dehnou, Vahid Tavakoli, Seyed A Gahreman, Daniel E J Diabetes Investig Articles AIMS/INTRODUCTION: To investigate the effect of endurance training on hippocampus DJ‐1 and cannabinoid receptor type 2 (CB (2)) protein and blood glucose concentration in diabetic rats. MATERIALS AND METHODS: A total of 32 rats were randomly divided into diabetic (D), diabetic and exercise (DE), exercise (E) and control (C) groups. The endurance training was carried out five times per week for 6 weeks. The hippocampus DJ‐1 and CB (2) were measured using an enzyme‐linked immunosorbent assay method. RESULTS: The level of DJ‐1 in the D group was significantly higher than the other groups (P ≤ 0.01). However, the level of DJ‐1 was not significantly different between the C, E and DE groups. In addition, the level of CB (2) was significantly lower in the D group compared with the other groups (P ≤ 0.01). Blood glucose was significantly higher in the D group compared with the DE group (P ≤ 0.05). Furthermore, a significant positive correlation between the level of DJ‐1 and blood glucose was observed (r = 0.67, P ≤ 0.001). There was also a significant inverse correlation between the level of CB (2) and blood glucose (r = −0.77, P ≤ 0.001). CONCLUSIONS: The results of this study suggest that the level of DJ‐1 and CB (2) might change in response to diabetes, and regular aerobic exercise could mediate the effect of DJ‐1 and CB (2) on diabetes‐induced neurodegenerative diseases. John Wiley and Sons Inc. 2018-06-14 2019-01 /pmc/articles/PMC6319482/ /pubmed/29791076 http://dx.doi.org/10.1111/jdi.12868 Text en © 2018 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Articles
Kurd, Mohammad
Valipour Dehnou, Vahid
Tavakoli, Seyed A
Gahreman, Daniel E
Effects of endurance training on hippocampus DJ‐1, cannabinoid receptor type 2 and blood glucose concentration in diabetic rats
title Effects of endurance training on hippocampus DJ‐1, cannabinoid receptor type 2 and blood glucose concentration in diabetic rats
title_full Effects of endurance training on hippocampus DJ‐1, cannabinoid receptor type 2 and blood glucose concentration in diabetic rats
title_fullStr Effects of endurance training on hippocampus DJ‐1, cannabinoid receptor type 2 and blood glucose concentration in diabetic rats
title_full_unstemmed Effects of endurance training on hippocampus DJ‐1, cannabinoid receptor type 2 and blood glucose concentration in diabetic rats
title_short Effects of endurance training on hippocampus DJ‐1, cannabinoid receptor type 2 and blood glucose concentration in diabetic rats
title_sort effects of endurance training on hippocampus dj‐1, cannabinoid receptor type 2 and blood glucose concentration in diabetic rats
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319482/
https://www.ncbi.nlm.nih.gov/pubmed/29791076
http://dx.doi.org/10.1111/jdi.12868
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