Alpha the versatile: Guardians of the islets

Recent progress in α‐cell research has newly revealed its versatility including secretion of multiple hormones, trans‐differentiation, and abundant proliferation. A recent report from the Kushner laboratory further provided direct evidence of active proliferation of α‐cells in both T1D and non‐diabe...

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Detalles Bibliográficos
Autor principal: Kawamori, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319495/
https://www.ncbi.nlm.nih.gov/pubmed/29906335
http://dx.doi.org/10.1111/jdi.12875
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author Kawamori, Dan
author_facet Kawamori, Dan
author_sort Kawamori, Dan
collection PubMed
description Recent progress in α‐cell research has newly revealed its versatility including secretion of multiple hormones, trans‐differentiation, and abundant proliferation. A recent report from the Kushner laboratory further provided direct evidence of active proliferation of α‐cells in both T1D and non‐diabetic control donors. α‐cells are suggested to maintain both quality and quantity of islets by serving as ‘guardians’ of the islets. [Image: see text]
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spelling pubmed-63194952019-01-08 Alpha the versatile: Guardians of the islets Kawamori, Dan J Diabetes Investig Commentaries Recent progress in α‐cell research has newly revealed its versatility including secretion of multiple hormones, trans‐differentiation, and abundant proliferation. A recent report from the Kushner laboratory further provided direct evidence of active proliferation of α‐cells in both T1D and non‐diabetic control donors. α‐cells are suggested to maintain both quality and quantity of islets by serving as ‘guardians’ of the islets. [Image: see text] John Wiley and Sons Inc. 2018-07-25 2019-01 /pmc/articles/PMC6319495/ /pubmed/29906335 http://dx.doi.org/10.1111/jdi.12875 Text en © 2018 The Author. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Commentaries
Kawamori, Dan
Alpha the versatile: Guardians of the islets
title Alpha the versatile: Guardians of the islets
title_full Alpha the versatile: Guardians of the islets
title_fullStr Alpha the versatile: Guardians of the islets
title_full_unstemmed Alpha the versatile: Guardians of the islets
title_short Alpha the versatile: Guardians of the islets
title_sort alpha the versatile: guardians of the islets
topic Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319495/
https://www.ncbi.nlm.nih.gov/pubmed/29906335
http://dx.doi.org/10.1111/jdi.12875
work_keys_str_mv AT kawamoridan alphatheversatileguardiansoftheislets

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