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Shikonin Exerts Cytotoxic Effects in Human Colon Cancers by Inducing Apoptotic Cell Death via the Endoplasmic Reticulum and Mitochondria-Mediated Pathways

The apoptotic effects of shikonin (5,8-dihydroxy-2-[(1R)-1-hydroxy-4-methylpent-3-enyl]naphthalene-1,4-dione) on the human colon cancer cell line SNU-407 were investigated in this study. Shikonin showed dose-dependent cytotoxic activity against SNU-407 cells, with an estimated IC(50) value of 3 µM a...

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Detalles Bibliográficos
Autores principales:	Han, Xia, Kang, Kyoung Ah, Piao, Mei Jing, Zhen, Ao Xuan, Hyun, Yu Jae, Kim, Hyun Min, Ryu, Yea Seong, Hyun, Jin Won
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Korean Society of Applied Pharmacology 2019
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319547/ https://www.ncbi.nlm.nih.gov/pubmed/29925224 http://dx.doi.org/10.4062/biomolther.2018.047

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