Regulation of Neural Stem Cell Fate by Natural Products

Neural stem cells (NSCs) can proliferate and differentiate into multiple cell types that constitute the nervous system. NSCs can be derived from developing fetuses, embryonic stem cells, or induced pluripotent stem cells. NSCs provide a good platform to screen drugs for neurodegenerative diseases an...

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Autor principal: Kim, Hyun-Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Applied Pharmacology 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319553/
https://www.ncbi.nlm.nih.gov/pubmed/30481958
http://dx.doi.org/10.4062/biomolther.2018.184
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author Kim, Hyun-Jung
author_facet Kim, Hyun-Jung
author_sort Kim, Hyun-Jung
collection PubMed
description Neural stem cells (NSCs) can proliferate and differentiate into multiple cell types that constitute the nervous system. NSCs can be derived from developing fetuses, embryonic stem cells, or induced pluripotent stem cells. NSCs provide a good platform to screen drugs for neurodegenerative diseases and also have potential applications in regenerative medicine. Natural products have long been used as compounds to develop new drugs. In this review, natural products that control NSC fate and induce their differentiation into neurons or glia are discussed. These phytochemicals enable promising advances to be made in the treatment of neurodegenerative diseases.
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spelling pubmed-63195532019-01-17 Regulation of Neural Stem Cell Fate by Natural Products Kim, Hyun-Jung Biomol Ther (Seoul) Review Neural stem cells (NSCs) can proliferate and differentiate into multiple cell types that constitute the nervous system. NSCs can be derived from developing fetuses, embryonic stem cells, or induced pluripotent stem cells. NSCs provide a good platform to screen drugs for neurodegenerative diseases and also have potential applications in regenerative medicine. Natural products have long been used as compounds to develop new drugs. In this review, natural products that control NSC fate and induce their differentiation into neurons or glia are discussed. These phytochemicals enable promising advances to be made in the treatment of neurodegenerative diseases. The Korean Society of Applied Pharmacology 2019-01 2018-11-27 /pmc/articles/PMC6319553/ /pubmed/30481958 http://dx.doi.org/10.4062/biomolther.2018.184 Text en Copyright ©2019, The Korean Society of Applied Pharmacology http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Kim, Hyun-Jung
Regulation of Neural Stem Cell Fate by Natural Products
title Regulation of Neural Stem Cell Fate by Natural Products
title_full Regulation of Neural Stem Cell Fate by Natural Products
title_fullStr Regulation of Neural Stem Cell Fate by Natural Products
title_full_unstemmed Regulation of Neural Stem Cell Fate by Natural Products
title_short Regulation of Neural Stem Cell Fate by Natural Products
title_sort regulation of neural stem cell fate by natural products
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319553/
https://www.ncbi.nlm.nih.gov/pubmed/30481958
http://dx.doi.org/10.4062/biomolther.2018.184
work_keys_str_mv AT kimhyunjung regulationofneuralstemcellfatebynaturalproducts

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