Acute Ischemia Induced by High-Density Culture Increases Cytokine Expression and Diminishes the Function and Viability of Highly Purified Human Islets of Langerhans

BACKGROUND: Encapsulation devices have the potential to enable cell-based insulin replacement therapies (such as human islet or stem cell–derived β cell transplantation) without immunosuppression. However, reasonably sized encapsulation devices promote ischemia due to high β cell densities creating...

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Detalles Bibliográficos
Autores principales: Smith, Kate E., Kelly, Amy C., Min, Catherine G., Weber, Craig S., McCarthy, Fiona M., Steyn, Leah V., Badarinarayana, Vasudeo, Stanton, J. Brett, Kitzmann, Jennifer P., Strop, Peter, Gruessner, Angelika C., Lynch, Ronald M., Limesand, Sean W., Papas, Klearchos K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2017
Materias:
Original Basic Science—General
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319561/
https://www.ncbi.nlm.nih.gov/pubmed/28263224
http://dx.doi.org/10.1097/TP.0000000000001714

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