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Typhoid and paratyphoid fever: a call to action

PURPOSE OF REVIEW: Enteric fever remains a major global-health concern, estimated to be responsible for between 11.9 and 26.9 million cases annually. Long-term prevention of enteric fever will require improved access to safe drinking water combined with investment in sanitation and hygiene intervent...

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Autores principales: Gibani, Malick M., Britto, Carl, Pollard, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319573/
https://www.ncbi.nlm.nih.gov/pubmed/30138141
http://dx.doi.org/10.1097/QCO.0000000000000479
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author Gibani, Malick M.
Britto, Carl
Pollard, Andrew J.
author_facet Gibani, Malick M.
Britto, Carl
Pollard, Andrew J.
author_sort Gibani, Malick M.
collection PubMed
description PURPOSE OF REVIEW: Enteric fever remains a major global-health concern, estimated to be responsible for between 11.9 and 26.9 million cases annually. Long-term prevention of enteric fever will require improved access to safe drinking water combined with investment in sanitation and hygiene interventions. In the short-to-medium term, new control strategies for typhoid fever have arrived in the form of typhoid Vi-conjugate vaccines (TCVs), offering hope that disease control can be achieved in the near future. RECENT FINDINGS: The diagnosis of enteric fever is complicated by its nonspecific clinical presentation, coupled with the low sensitivity of commonly used diagnostics. Investment in diagnostics has the potential to improve management, to refine estimates of disease burden and to facilitate vaccine impact studies. A new generation of reliable, diagnostic tests is needed that are simultaneously accessible, cost-effective, sensitive, and specific. The emergence and global dissemination of multidrug-resistant, fluoroquinolone-resistant, and extensively drug-resistant (XDR) strains of Salmonella Typhi emphasizes the importance of continued surveillance and appropriate antibiotic stewardship, integrated into a global strategy to address antimicrobial resistance (AMR). Current empirical treatment guidelines are out of date and should be updated to respond to local trends in AMR, so as to guide treatment choices in the absence of robust diagnostics and laboratory facilities. In September 2017, the WHO Strategic Advisory Group of Experts (SAGE) immunization recommended the programmatic use of TCVs in high burden countries. Ongoing and future studies should aim to study the impact of these vaccines in a diverse range of setting and to support the deployment of TCVs in high-burden countries. SUMMARY: The advent of new generation TCVs offers us a practical and affordable public-health tool that – for the first time – can be integrated into routine childhood immunization programmes. In this review, we advocate for the deployment of TCVs in line with WHO recommendations, to improve child health and limit the spread of antibiotic-resistant S. Typhi.
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spelling pubmed-63195732019-01-18 Typhoid and paratyphoid fever: a call to action Gibani, Malick M. Britto, Carl Pollard, Andrew J. Curr Opin Infect Dis GASTROINTESTINAL INFECTIONS: Edited by A Clinton White and Gagandeep Kang PURPOSE OF REVIEW: Enteric fever remains a major global-health concern, estimated to be responsible for between 11.9 and 26.9 million cases annually. Long-term prevention of enteric fever will require improved access to safe drinking water combined with investment in sanitation and hygiene interventions. In the short-to-medium term, new control strategies for typhoid fever have arrived in the form of typhoid Vi-conjugate vaccines (TCVs), offering hope that disease control can be achieved in the near future. RECENT FINDINGS: The diagnosis of enteric fever is complicated by its nonspecific clinical presentation, coupled with the low sensitivity of commonly used diagnostics. Investment in diagnostics has the potential to improve management, to refine estimates of disease burden and to facilitate vaccine impact studies. A new generation of reliable, diagnostic tests is needed that are simultaneously accessible, cost-effective, sensitive, and specific. The emergence and global dissemination of multidrug-resistant, fluoroquinolone-resistant, and extensively drug-resistant (XDR) strains of Salmonella Typhi emphasizes the importance of continued surveillance and appropriate antibiotic stewardship, integrated into a global strategy to address antimicrobial resistance (AMR). Current empirical treatment guidelines are out of date and should be updated to respond to local trends in AMR, so as to guide treatment choices in the absence of robust diagnostics and laboratory facilities. In September 2017, the WHO Strategic Advisory Group of Experts (SAGE) immunization recommended the programmatic use of TCVs in high burden countries. Ongoing and future studies should aim to study the impact of these vaccines in a diverse range of setting and to support the deployment of TCVs in high-burden countries. SUMMARY: The advent of new generation TCVs offers us a practical and affordable public-health tool that – for the first time – can be integrated into routine childhood immunization programmes. In this review, we advocate for the deployment of TCVs in line with WHO recommendations, to improve child health and limit the spread of antibiotic-resistant S. Typhi. Lippincott Williams & Wilkins 2018-10 2018-08-17 /pmc/articles/PMC6319573/ /pubmed/30138141 http://dx.doi.org/10.1097/QCO.0000000000000479 Text en Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0, (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle GASTROINTESTINAL INFECTIONS: Edited by A Clinton White and Gagandeep Kang
Gibani, Malick M.
Britto, Carl
Pollard, Andrew J.
Typhoid and paratyphoid fever: a call to action
title Typhoid and paratyphoid fever: a call to action
title_full Typhoid and paratyphoid fever: a call to action
title_fullStr Typhoid and paratyphoid fever: a call to action
title_full_unstemmed Typhoid and paratyphoid fever: a call to action
title_short Typhoid and paratyphoid fever: a call to action
title_sort typhoid and paratyphoid fever: a call to action
topic GASTROINTESTINAL INFECTIONS: Edited by A Clinton White and Gagandeep Kang
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319573/
https://www.ncbi.nlm.nih.gov/pubmed/30138141
http://dx.doi.org/10.1097/QCO.0000000000000479
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