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Activity of xanthine oxidase in plasma correlates with indices of insulin resistance and liver dysfunction in patients with type 2 diabetes mellitus and metabolic syndrome: A pilot exploratory study
AIMS/INTRODUCTION: There is controversy as to whether hyperuricemia is an independent risk factor for cardiometabolic diseases. The serum level of uric acid is affected by a wide variety of factors involved in its production and excretion. In contrast, evidence has accumulated that locally‐ and syst...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319612/ https://www.ncbi.nlm.nih.gov/pubmed/29862667 http://dx.doi.org/10.1111/jdi.12870 |
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author | Sunagawa, Sumito Shirakura, Takashi Hokama, Noboru Kozuka, Chisayo Yonamine, Masato Namba, Toyotaka Morishima, Satoko Nakachi, Sawako Nishi, Yukiko Ikema, Tomomi Okamoto, Shiki Matsui, Chieko Hase, Naoki Tamura, Mizuho Shimabukuro, Michio Masuzaki, Hiroaki |
author_facet | Sunagawa, Sumito Shirakura, Takashi Hokama, Noboru Kozuka, Chisayo Yonamine, Masato Namba, Toyotaka Morishima, Satoko Nakachi, Sawako Nishi, Yukiko Ikema, Tomomi Okamoto, Shiki Matsui, Chieko Hase, Naoki Tamura, Mizuho Shimabukuro, Michio Masuzaki, Hiroaki |
author_sort | Sunagawa, Sumito |
collection | PubMed |
description | AIMS/INTRODUCTION: There is controversy as to whether hyperuricemia is an independent risk factor for cardiometabolic diseases. The serum level of uric acid is affected by a wide variety of factors involved in its production and excretion. In contrast, evidence has accumulated that locally‐ and systemically‐activated xanthine oxidase (XO), a rate‐limiting enzyme for production of uric acid, is linked to metabolic derangement in humans and rodents. We therefore explored the clinical implication of plasma XO activity in patients with type 2 diabetes mellitus and metabolic syndrome (MetS). MATERIALS AND METHODS: We enrolled 60 patients with type 2 diabetes mellitus and MetS. MetS was defined according to the 2005 International Diabetes Federation guidelines. Plasma XO activity was measured by highly‐sensitive fluorometric assay measuring the conversion of pterin to isoxanthopterin, and explored associations between the value of plasma XO activity and metabolic parameters. RESULTS: The value of plasma XO activity was correlated with indices of insulin resistance and the level of circulating liver transaminases. In contrast, the level of serum uric acid was not correlated with indices of insulin resistance. The value of plasma XO activity was not correlated with the serum uric acid level. CONCLUSIONS: Plasma XO activity correlates with indices of insulin resistance and liver dysfunction in Japanese patients with type 2 diabetes mellitus and MetS. Through assessing the plasma XO activity, patients showing normal levels of serum uric acid with higher activity of XO can be screened, thereby possibly providing a clue to uncovering metabolic risks in type 2 diabetes mellitus and MetS patients. |
format | Online Article Text |
id | pubmed-6319612 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-63196122019-01-08 Activity of xanthine oxidase in plasma correlates with indices of insulin resistance and liver dysfunction in patients with type 2 diabetes mellitus and metabolic syndrome: A pilot exploratory study Sunagawa, Sumito Shirakura, Takashi Hokama, Noboru Kozuka, Chisayo Yonamine, Masato Namba, Toyotaka Morishima, Satoko Nakachi, Sawako Nishi, Yukiko Ikema, Tomomi Okamoto, Shiki Matsui, Chieko Hase, Naoki Tamura, Mizuho Shimabukuro, Michio Masuzaki, Hiroaki J Diabetes Investig Articles AIMS/INTRODUCTION: There is controversy as to whether hyperuricemia is an independent risk factor for cardiometabolic diseases. The serum level of uric acid is affected by a wide variety of factors involved in its production and excretion. In contrast, evidence has accumulated that locally‐ and systemically‐activated xanthine oxidase (XO), a rate‐limiting enzyme for production of uric acid, is linked to metabolic derangement in humans and rodents. We therefore explored the clinical implication of plasma XO activity in patients with type 2 diabetes mellitus and metabolic syndrome (MetS). MATERIALS AND METHODS: We enrolled 60 patients with type 2 diabetes mellitus and MetS. MetS was defined according to the 2005 International Diabetes Federation guidelines. Plasma XO activity was measured by highly‐sensitive fluorometric assay measuring the conversion of pterin to isoxanthopterin, and explored associations between the value of plasma XO activity and metabolic parameters. RESULTS: The value of plasma XO activity was correlated with indices of insulin resistance and the level of circulating liver transaminases. In contrast, the level of serum uric acid was not correlated with indices of insulin resistance. The value of plasma XO activity was not correlated with the serum uric acid level. CONCLUSIONS: Plasma XO activity correlates with indices of insulin resistance and liver dysfunction in Japanese patients with type 2 diabetes mellitus and MetS. Through assessing the plasma XO activity, patients showing normal levels of serum uric acid with higher activity of XO can be screened, thereby possibly providing a clue to uncovering metabolic risks in type 2 diabetes mellitus and MetS patients. John Wiley and Sons Inc. 2018-07-07 2019-01 /pmc/articles/PMC6319612/ /pubmed/29862667 http://dx.doi.org/10.1111/jdi.12870 Text en © 2018 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Articles Sunagawa, Sumito Shirakura, Takashi Hokama, Noboru Kozuka, Chisayo Yonamine, Masato Namba, Toyotaka Morishima, Satoko Nakachi, Sawako Nishi, Yukiko Ikema, Tomomi Okamoto, Shiki Matsui, Chieko Hase, Naoki Tamura, Mizuho Shimabukuro, Michio Masuzaki, Hiroaki Activity of xanthine oxidase in plasma correlates with indices of insulin resistance and liver dysfunction in patients with type 2 diabetes mellitus and metabolic syndrome: A pilot exploratory study |
title | Activity of xanthine oxidase in plasma correlates with indices of insulin resistance and liver dysfunction in patients with type 2 diabetes mellitus and metabolic syndrome: A pilot exploratory study |
title_full | Activity of xanthine oxidase in plasma correlates with indices of insulin resistance and liver dysfunction in patients with type 2 diabetes mellitus and metabolic syndrome: A pilot exploratory study |
title_fullStr | Activity of xanthine oxidase in plasma correlates with indices of insulin resistance and liver dysfunction in patients with type 2 diabetes mellitus and metabolic syndrome: A pilot exploratory study |
title_full_unstemmed | Activity of xanthine oxidase in plasma correlates with indices of insulin resistance and liver dysfunction in patients with type 2 diabetes mellitus and metabolic syndrome: A pilot exploratory study |
title_short | Activity of xanthine oxidase in plasma correlates with indices of insulin resistance and liver dysfunction in patients with type 2 diabetes mellitus and metabolic syndrome: A pilot exploratory study |
title_sort | activity of xanthine oxidase in plasma correlates with indices of insulin resistance and liver dysfunction in patients with type 2 diabetes mellitus and metabolic syndrome: a pilot exploratory study |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319612/ https://www.ncbi.nlm.nih.gov/pubmed/29862667 http://dx.doi.org/10.1111/jdi.12870 |
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