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Increased TFAM binding to mtDNA damage hot spots is associated with mtDNA loss in aged rat heart

The well-known age-related mitochondrial dysfunction deeply affects heart because of the tissue’s large dependence on mitochondrial ATP provision. Our study revealed in aged rat heart a significant 25% decrease in mtDNA relative content, a significant 29% increase in the 4.8 Kb mtDNA deletion relati...

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Detalles Bibliográficos
Autores principales:	Chimienti, Guglielmina, Picca, Anna, Sirago, Giuseppe, Fracasso, Flavio, Calvani, Riccardo, Bernabei, Roberto, Russo, Francesco, Carter, Christy S., Leeuwenburgh, Christiaan, Pesce, Vito, Marzetti, Emanuele, Lezza, Angela Maria Serena
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319621/ https://www.ncbi.nlm.nih.gov/pubmed/29969715 http://dx.doi.org/10.1016/j.freeradbiomed.2018.06.041

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