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Antineutrophil cytoplasmic antibody-positive familial Mediterranean fever and hyperthyroidism: A case report
RATIONALE: Familial Mediterranean fever (FMF) is a genetic autoinflammatory disorder characterized by serositis and recurrent fever. Previous reports identified patients with antineutrophil cytoplasmic antibody (ANCA)-positive FMF, but vasculitis symptoms were not reported. PATIENT CONCERNS: We repo...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319784/ https://www.ncbi.nlm.nih.gov/pubmed/30572542 http://dx.doi.org/10.1097/MD.0000000000013805 |
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author | Segoe, Sorato Sada, Ken-ei Hayashi, Keigo Yamamura, Yuriko Morishita, Michiko Watanabe, Haruki Matsumoto, Yoshinori Wada, Jun |
author_facet | Segoe, Sorato Sada, Ken-ei Hayashi, Keigo Yamamura, Yuriko Morishita, Michiko Watanabe, Haruki Matsumoto, Yoshinori Wada, Jun |
author_sort | Segoe, Sorato |
collection | PubMed |
description | RATIONALE: Familial Mediterranean fever (FMF) is a genetic autoinflammatory disorder characterized by serositis and recurrent fever. Previous reports identified patients with antineutrophil cytoplasmic antibody (ANCA)-positive FMF, but vasculitis symptoms were not reported. PATIENT CONCERNS: We report the case of a 44-year-old man with numbness. He had a history of 3 episodes of pleurisy and was being treated with propylthiouracil for hyperthyroidism. Because he was ANCA-positive, we suspected drug-induced ANCA-associated vasculitis and propylthiouracil was discontinued. However, his numbness was not ameliorated, and he again developed high fever with pleurisy. DIAGNOSIS: Diagnosis of FMF was finally made, and genetic analysis revealed compound heterozygous mutations in exon 2 of the familial Mediterranean fever gene (L110P/E148Q). INTERVENTIONS: The patient was treated with 0.5 mg/day of colchicine. OUTCOMES: His numbness improved, and fever has not recurred. LESSONS: Appearance of ANCA and development of vasculitis should be considered in a clinical course of FMF with hyperthyroidism. |
format | Online Article Text |
id | pubmed-6319784 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-63197842019-01-24 Antineutrophil cytoplasmic antibody-positive familial Mediterranean fever and hyperthyroidism: A case report Segoe, Sorato Sada, Ken-ei Hayashi, Keigo Yamamura, Yuriko Morishita, Michiko Watanabe, Haruki Matsumoto, Yoshinori Wada, Jun Medicine (Baltimore) Research Article RATIONALE: Familial Mediterranean fever (FMF) is a genetic autoinflammatory disorder characterized by serositis and recurrent fever. Previous reports identified patients with antineutrophil cytoplasmic antibody (ANCA)-positive FMF, but vasculitis symptoms were not reported. PATIENT CONCERNS: We report the case of a 44-year-old man with numbness. He had a history of 3 episodes of pleurisy and was being treated with propylthiouracil for hyperthyroidism. Because he was ANCA-positive, we suspected drug-induced ANCA-associated vasculitis and propylthiouracil was discontinued. However, his numbness was not ameliorated, and he again developed high fever with pleurisy. DIAGNOSIS: Diagnosis of FMF was finally made, and genetic analysis revealed compound heterozygous mutations in exon 2 of the familial Mediterranean fever gene (L110P/E148Q). INTERVENTIONS: The patient was treated with 0.5 mg/day of colchicine. OUTCOMES: His numbness improved, and fever has not recurred. LESSONS: Appearance of ANCA and development of vasculitis should be considered in a clinical course of FMF with hyperthyroidism. Wolters Kluwer Health 2018-12-21 /pmc/articles/PMC6319784/ /pubmed/30572542 http://dx.doi.org/10.1097/MD.0000000000013805 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | Research Article Segoe, Sorato Sada, Ken-ei Hayashi, Keigo Yamamura, Yuriko Morishita, Michiko Watanabe, Haruki Matsumoto, Yoshinori Wada, Jun Antineutrophil cytoplasmic antibody-positive familial Mediterranean fever and hyperthyroidism: A case report |
title | Antineutrophil cytoplasmic antibody-positive familial Mediterranean fever and hyperthyroidism: A case report |
title_full | Antineutrophil cytoplasmic antibody-positive familial Mediterranean fever and hyperthyroidism: A case report |
title_fullStr | Antineutrophil cytoplasmic antibody-positive familial Mediterranean fever and hyperthyroidism: A case report |
title_full_unstemmed | Antineutrophil cytoplasmic antibody-positive familial Mediterranean fever and hyperthyroidism: A case report |
title_short | Antineutrophil cytoplasmic antibody-positive familial Mediterranean fever and hyperthyroidism: A case report |
title_sort | antineutrophil cytoplasmic antibody-positive familial mediterranean fever and hyperthyroidism: a case report |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319784/ https://www.ncbi.nlm.nih.gov/pubmed/30572542 http://dx.doi.org/10.1097/MD.0000000000013805 |
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