Sepsis-induced Takotsubo syndrome in young premenopausal women: Two case reports

RATIONALE: Takotsubo syndrome (TTS) most commonly occurs in postmenopausal women who have been exposed to a triggering event such as acute physical or emotional distress. Sepsis-induced TTS in young premenopausal women were rarely reported. In particular, the relationship between sepsis-induced TTS and sepsis-induced cardiomyopathy (SIC) remains to be illuminated. PATIENT CONCERNS: Two young premenopausal women were admitted to the hospital with sepsis and myocardial involvement. DIAGNOSIS: Both patients fully met the Mayo Clinic criteria for TTS. INTERVENTIONS: Both patients received anti-infection and fluid infusion treatment. OUTCOMES: Both patients were discharged without complications and the follow-up ultrasonic echocardiography showed normal results. LESSONS: In this report, we describe 2 young premenopausal women with sepsis-induced TTS. There is an overlap between sepsis-induced TTS and SIC, and SIC could be a special type of TTS, which occurs under the stress of sepsis.