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Comprehensive Review of Molecular Mechanisms during Cholestatic Liver Injury and Cholangiocarcinoma
Cholestatic liver injury is characterized by damage induced on the biliary tree and cholangiocytes, the cells lining the biliary tree, thus they are termed “cholangiopathies”. Cholangiopathies include diseases such as Primary Biliary Cholangitis, Primary Sclerosing Cholangitis, Biliary Atresia and C...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319937/ https://www.ncbi.nlm.nih.gov/pubmed/30613437 http://dx.doi.org/10.4172/2167-0889.1000231 |
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author | Virani, Shohaib Akers, Austin Stephenson, Kristen Smith, Steven Kennedy, Lindsey Alpini, Gianfranco Francis, Heather |
author_facet | Virani, Shohaib Akers, Austin Stephenson, Kristen Smith, Steven Kennedy, Lindsey Alpini, Gianfranco Francis, Heather |
author_sort | Virani, Shohaib |
collection | PubMed |
description | Cholestatic liver injury is characterized by damage induced on the biliary tree and cholangiocytes, the cells lining the biliary tree, thus they are termed “cholangiopathies”. Cholangiopathies include diseases such as Primary Biliary Cholangitis, Primary Sclerosing Cholangitis, Biliary Atresia and Cholangiocarcinoma. These pathologies lack viable therapies and most patients are diagnosed during late stage disease progression (with the exception of Biliary Atresia, which is found shortly after birth). The lack of therapies for these diseases has put a significant burden on the need for liver transplantation as this is the only indicative “cure” for cholangiopathies. The molecular mechanisms for cholangiopathies have been extensively studied; however, and unfortunately, the lack of effective biomarkers and therapeutics remains. In this review article we highlight the latest studies to investigate the molecular mechanisms regulating cholangiopathies and the potential therapeutics that might be discovered. |
format | Online Article Text |
id | pubmed-6319937 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
record_format | MEDLINE/PubMed |
spelling | pubmed-63199372019-01-04 Comprehensive Review of Molecular Mechanisms during Cholestatic Liver Injury and Cholangiocarcinoma Virani, Shohaib Akers, Austin Stephenson, Kristen Smith, Steven Kennedy, Lindsey Alpini, Gianfranco Francis, Heather J Liver Article Cholestatic liver injury is characterized by damage induced on the biliary tree and cholangiocytes, the cells lining the biliary tree, thus they are termed “cholangiopathies”. Cholangiopathies include diseases such as Primary Biliary Cholangitis, Primary Sclerosing Cholangitis, Biliary Atresia and Cholangiocarcinoma. These pathologies lack viable therapies and most patients are diagnosed during late stage disease progression (with the exception of Biliary Atresia, which is found shortly after birth). The lack of therapies for these diseases has put a significant burden on the need for liver transplantation as this is the only indicative “cure” for cholangiopathies. The molecular mechanisms for cholangiopathies have been extensively studied; however, and unfortunately, the lack of effective biomarkers and therapeutics remains. In this review article we highlight the latest studies to investigate the molecular mechanisms regulating cholangiopathies and the potential therapeutics that might be discovered. 2018-09-20 2018 /pmc/articles/PMC6319937/ /pubmed/30613437 http://dx.doi.org/10.4172/2167-0889.1000231 Text en http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Article Virani, Shohaib Akers, Austin Stephenson, Kristen Smith, Steven Kennedy, Lindsey Alpini, Gianfranco Francis, Heather Comprehensive Review of Molecular Mechanisms during Cholestatic Liver Injury and Cholangiocarcinoma |
title | Comprehensive Review of Molecular Mechanisms during Cholestatic Liver Injury and Cholangiocarcinoma |
title_full | Comprehensive Review of Molecular Mechanisms during Cholestatic Liver Injury and Cholangiocarcinoma |
title_fullStr | Comprehensive Review of Molecular Mechanisms during Cholestatic Liver Injury and Cholangiocarcinoma |
title_full_unstemmed | Comprehensive Review of Molecular Mechanisms during Cholestatic Liver Injury and Cholangiocarcinoma |
title_short | Comprehensive Review of Molecular Mechanisms during Cholestatic Liver Injury and Cholangiocarcinoma |
title_sort | comprehensive review of molecular mechanisms during cholestatic liver injury and cholangiocarcinoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319937/ https://www.ncbi.nlm.nih.gov/pubmed/30613437 http://dx.doi.org/10.4172/2167-0889.1000231 |
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