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Comprehensive Review of Molecular Mechanisms during Cholestatic Liver Injury and Cholangiocarcinoma

Cholestatic liver injury is characterized by damage induced on the biliary tree and cholangiocytes, the cells lining the biliary tree, thus they are termed “cholangiopathies”. Cholangiopathies include diseases such as Primary Biliary Cholangitis, Primary Sclerosing Cholangitis, Biliary Atresia and C...

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Autores principales: Virani, Shohaib, Akers, Austin, Stephenson, Kristen, Smith, Steven, Kennedy, Lindsey, Alpini, Gianfranco, Francis, Heather
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319937/
https://www.ncbi.nlm.nih.gov/pubmed/30613437
http://dx.doi.org/10.4172/2167-0889.1000231
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author Virani, Shohaib
Akers, Austin
Stephenson, Kristen
Smith, Steven
Kennedy, Lindsey
Alpini, Gianfranco
Francis, Heather
author_facet Virani, Shohaib
Akers, Austin
Stephenson, Kristen
Smith, Steven
Kennedy, Lindsey
Alpini, Gianfranco
Francis, Heather
author_sort Virani, Shohaib
collection PubMed
description Cholestatic liver injury is characterized by damage induced on the biliary tree and cholangiocytes, the cells lining the biliary tree, thus they are termed “cholangiopathies”. Cholangiopathies include diseases such as Primary Biliary Cholangitis, Primary Sclerosing Cholangitis, Biliary Atresia and Cholangiocarcinoma. These pathologies lack viable therapies and most patients are diagnosed during late stage disease progression (with the exception of Biliary Atresia, which is found shortly after birth). The lack of therapies for these diseases has put a significant burden on the need for liver transplantation as this is the only indicative “cure” for cholangiopathies. The molecular mechanisms for cholangiopathies have been extensively studied; however, and unfortunately, the lack of effective biomarkers and therapeutics remains. In this review article we highlight the latest studies to investigate the molecular mechanisms regulating cholangiopathies and the potential therapeutics that might be discovered.
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spelling pubmed-63199372019-01-04 Comprehensive Review of Molecular Mechanisms during Cholestatic Liver Injury and Cholangiocarcinoma Virani, Shohaib Akers, Austin Stephenson, Kristen Smith, Steven Kennedy, Lindsey Alpini, Gianfranco Francis, Heather J Liver Article Cholestatic liver injury is characterized by damage induced on the biliary tree and cholangiocytes, the cells lining the biliary tree, thus they are termed “cholangiopathies”. Cholangiopathies include diseases such as Primary Biliary Cholangitis, Primary Sclerosing Cholangitis, Biliary Atresia and Cholangiocarcinoma. These pathologies lack viable therapies and most patients are diagnosed during late stage disease progression (with the exception of Biliary Atresia, which is found shortly after birth). The lack of therapies for these diseases has put a significant burden on the need for liver transplantation as this is the only indicative “cure” for cholangiopathies. The molecular mechanisms for cholangiopathies have been extensively studied; however, and unfortunately, the lack of effective biomarkers and therapeutics remains. In this review article we highlight the latest studies to investigate the molecular mechanisms regulating cholangiopathies and the potential therapeutics that might be discovered. 2018-09-20 2018 /pmc/articles/PMC6319937/ /pubmed/30613437 http://dx.doi.org/10.4172/2167-0889.1000231 Text en http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Virani, Shohaib
Akers, Austin
Stephenson, Kristen
Smith, Steven
Kennedy, Lindsey
Alpini, Gianfranco
Francis, Heather
Comprehensive Review of Molecular Mechanisms during Cholestatic Liver Injury and Cholangiocarcinoma
title Comprehensive Review of Molecular Mechanisms during Cholestatic Liver Injury and Cholangiocarcinoma
title_full Comprehensive Review of Molecular Mechanisms during Cholestatic Liver Injury and Cholangiocarcinoma
title_fullStr Comprehensive Review of Molecular Mechanisms during Cholestatic Liver Injury and Cholangiocarcinoma
title_full_unstemmed Comprehensive Review of Molecular Mechanisms during Cholestatic Liver Injury and Cholangiocarcinoma
title_short Comprehensive Review of Molecular Mechanisms during Cholestatic Liver Injury and Cholangiocarcinoma
title_sort comprehensive review of molecular mechanisms during cholestatic liver injury and cholangiocarcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319937/
https://www.ncbi.nlm.nih.gov/pubmed/30613437
http://dx.doi.org/10.4172/2167-0889.1000231
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