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Oncological markers CA-125, CA 19-9 and endometriosis

The endometrium tissue is functionally androgen related which plays an important role in women's fertility regulation. In addition recent findings show that endometrium related pathology is closely linked to disrupted androgen biosynthesis and associated regulatory functions. These findings als...

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Autores principales: Fiala, Ludek, Bob, Petr, Raboch, Jiri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320090/
https://www.ncbi.nlm.nih.gov/pubmed/30572523
http://dx.doi.org/10.1097/MD.0000000000013759
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author Fiala, Ludek
Bob, Petr
Raboch, Jiri
author_facet Fiala, Ludek
Bob, Petr
Raboch, Jiri
author_sort Fiala, Ludek
collection PubMed
description The endometrium tissue is functionally androgen related which plays an important role in women's fertility regulation. In addition recent findings show that endometrium related pathology is closely linked to disrupted androgen biosynthesis and associated regulatory functions. These findings also suggest that androgens might play an important role in endometrium related cancer pathology with significant implications for treatment. Based on these findings, we have assessed 50 female outpatients with endometriosis and the clinical investigations were focused on biochemical serum analysis of DHEAS, oncological markers CA-125 and CA 19-9, estradiol, thyreothropic hormone, and prolactin. The results show significant Spearman correlations of CA-125 and CA 19-9 with dehydroepiandrosterone- DHEA-S (R = 0.52 resp. R = 0.49). This result represents 1st reported finding documenting androgen related increase of CA-125 and CA 19-9 levels as significant markers of endometrium pathology and it is possible to assume that these potential biomarkers could have clinical importance with respect to timely diagnosis.
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spelling pubmed-63200902019-01-14 Oncological markers CA-125, CA 19-9 and endometriosis Fiala, Ludek Bob, Petr Raboch, Jiri Medicine (Baltimore) Research Article The endometrium tissue is functionally androgen related which plays an important role in women's fertility regulation. In addition recent findings show that endometrium related pathology is closely linked to disrupted androgen biosynthesis and associated regulatory functions. These findings also suggest that androgens might play an important role in endometrium related cancer pathology with significant implications for treatment. Based on these findings, we have assessed 50 female outpatients with endometriosis and the clinical investigations were focused on biochemical serum analysis of DHEAS, oncological markers CA-125 and CA 19-9, estradiol, thyreothropic hormone, and prolactin. The results show significant Spearman correlations of CA-125 and CA 19-9 with dehydroepiandrosterone- DHEA-S (R = 0.52 resp. R = 0.49). This result represents 1st reported finding documenting androgen related increase of CA-125 and CA 19-9 levels as significant markers of endometrium pathology and it is possible to assume that these potential biomarkers could have clinical importance with respect to timely diagnosis. Wolters Kluwer Health 2018-12-21 /pmc/articles/PMC6320090/ /pubmed/30572523 http://dx.doi.org/10.1097/MD.0000000000013759 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle Research Article
Fiala, Ludek
Bob, Petr
Raboch, Jiri
Oncological markers CA-125, CA 19-9 and endometriosis
title Oncological markers CA-125, CA 19-9 and endometriosis
title_full Oncological markers CA-125, CA 19-9 and endometriosis
title_fullStr Oncological markers CA-125, CA 19-9 and endometriosis
title_full_unstemmed Oncological markers CA-125, CA 19-9 and endometriosis
title_short Oncological markers CA-125, CA 19-9 and endometriosis
title_sort oncological markers ca-125, ca 19-9 and endometriosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320090/
https://www.ncbi.nlm.nih.gov/pubmed/30572523
http://dx.doi.org/10.1097/MD.0000000000013759
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