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Improved potency of F10 relative to 5-fluorouracil in colorectal cancer cells with p53 mutations

AIM: Resistance to fluoropyrimidine drugs (FPs) is a major cause of mortality in colorectal cancer (CRC). We assessed the potency advantage of the polymeric FP F10 relative to 5-fluorouracil (5FU) in four human CRC cell lines that differ only in TP53 mutational status to determine how p53 mutations...

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Detalles Bibliográficos
Autores principales:	Dominijanni, Anthony, Gmeiner, William H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320232/ https://www.ncbi.nlm.nih.gov/pubmed/30613833 http://dx.doi.org/10.20517/cdr.2018.01

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