Cargando…

Inhibiting the Evolution of Antibiotic Resistance

Efforts to battle antimicrobial resistance (AMR) are generally focused on developing novel antibiotics. However, history shows that resistance arises regardless of the nature or potency of new drugs. Here, we propose and provide evidence for an alternate strategy to resolve this problem: inhibiting...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ragheb, Mark N., Thomason, Maureen K., Hsu, Chris, Nugent, Patrick, Gage, John, Samadpour, Ariana N., Kariisa, Ankunda, Merrikh, Christopher N., Miller, Samuel I., Sherman, David R., Merrikh, Houra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320318/ https://www.ncbi.nlm.nih.gov/pubmed/30449724 http://dx.doi.org/10.1016/j.molcel.2018.10.015

Ejemplares similares

The Accelerated Evolution of Lagging Strand Genes Is Independent of Sequence Context
por: Merrikh, Christopher N., et al.
Publicado: (2016)

Oxidative stress drives mutagenesis through transcription-coupled repair in bacteria
por: Carvajal-Garcia, Juan, et al.
Publicado: (2023)

The enigmatic role of Mfd in replication-transcription conflicts in bacteria
por: Ragheb, Mark, et al.
Publicado: (2019)

Gene inversion potentiates bacterial evolvability and virulence
por: Merrikh, Christopher N., et al.
Publicado: (2018)

Reply to: Testing the adaptive hypothesis of lagging-strand encoding in bacterial genomes
por: Merrikh, Houra, et al.
Publicado: (2022)

The B. subtilis Accessory Helicase PcrA Facilitates DNA Replication through Transcription Units
por: Merrikh, Christopher N., et al.
Publicado: (2015)

Transcription leads to pervasive replisome instability in bacteria
por: Mangiameli, Sarah M, et al.
Publicado: (2017)

Topological stress is responsible for the detrimental outcomes of head-on replication-transcription conflicts
por: Lang, Kevin S., et al.
Publicado: (2021)

Compensatory mutations improve general permissiveness to antibiotic resistance plasmids
por: Loftie-Eaton, Wesley, et al.
Publicado: (2017)

Pathogenic bacteria experience pervasive RNA polymerase backtracking during infection
por: Browning, Kaitlyn R., et al.
Publicado: (2023)

Crystal structure of a membrane-bound O-acyltransferase
por: Ma, Dan, et al.
Publicado: (2018)

The Replisomes Remain Spatially Proximal throughout the Cell Cycle in Bacteria
por: Mangiameli, Sarah M., et al.
Publicado: (2017)

Co-directional replication-transcription conflicts lead to replication restart
por: Merrikh, Houra, et al.
Publicado: (2011)

The in vivo measurement of replication fork velocity and pausing by lag-time analysis
por: Huang, Dean, et al.
Publicado: (2023)

ASC1 and RPS3: new actors in 18S nonfunctional rRNA decay
por: Limoncelli, Kelly A., et al.
Publicado: (2017)

The RNA Domain Vc1 Regulates Downstream Gene Expression in Response to Cyclic Diguanylate in Vibrio cholerae
por: Kariisa, Ankunda T., et al.
Publicado: (2016)

Two nucleotide second messengers regulate the production of the Vibrio cholerae colonization factor GbpA
por: Kariisa, Ankunda T., et al.
Publicado: (2015)

Comparison of the shear bond strength in Giomer and resin-modified glass ionomer in class V lesions
por: Zavare, Donya, et al.
Publicado: (2023)

Direct visualization of transcription-replication conflicts reveals post-replicative DNA:RNA hybrids
por: Stoy, Henriette, et al.
Publicado: (2023)

A systematic analysis of the in vitro and in vivo functions of the HD-GYP domain proteins of Vibrio cholerae
por: McKee, Robert W, et al.
Publicado: (2014)

Self-Adaptive Spike-Time-Dependent Plasticity of Metal-Oxide Memristors
por: Prezioso, M., et al.
Publicado: (2016)

Implementation of multilayer perceptron network with highly uniform passive memristive crossbar circuits
por: Bayat, F. Merrikh, et al.
Publicado: (2018)

Spike-timing-dependent plasticity learning of coincidence detection with passively integrated memristive circuits
por: Prezioso, M., et al.
Publicado: (2018)

Identification of genes induced in Vibrio cholerae in a dynamic biofilm system
por: Seper, Andrea, et al.
Publicado: (2014)

Modeling and Experimental Demonstration of a Hopfield Network Analog-to-Digital Converter with Hybrid CMOS/Memristor Circuits
por: Guo, Xinjie, et al.
Publicado: (2015)

Edwards–Wilkinson depinning transition in fractional Brownian motion background
por: Valizadeh, N., et al.
Publicado: (2023)

Inhibition of Mutation and Combating the Evolution of Antibiotic Resistance
por: Cirz, Ryan T, et al.
Publicado: (2005)

Targeting evolution of antibiotic resistance by SOS response inhibition
por: Yakimov, Alexander, et al.
Publicado: (2021)

Improving the parameters of electron transport in quantum dot sensitized solar cells through seed layer deposition
por: Samadpour, Mahmoud
Publicado: (2018)

Evolution of Antibiotic Resistance without Antibiotic Exposure
por: Knöppel, Anna, et al.
Publicado: (2017)

Sexual risk related behaviour among youth living with HIV in central Uganda: implications for HIV prevention
por: Ankunda, Racheal, et al.
Publicado: (2016)

Evolution of a transcriptional regulator from a transmembrane nucleoporin
por: Franks, Tobias M., et al.
Publicado: (2016)

The effects of concurrent training (aerobic-resistance) and milk consumption on some markers of bone mineral density in women with osteoporosis
por: Arazi, Hamid, et al.
Publicado: (2018)

Agrichemicals and antibiotics in combination increase antibiotic resistance evolution
por: Kurenbach, Brigitta, et al.
Publicado: (2018)

Appropriateness of Outpatient Antibiotic Use in Seniors across Two Canadian Provinces
por: Saatchi, Ariana, et al.
Publicado: (2021)

The idea generator: 15 clever thinking tools to create winning ideas quickly
por: Thomason, Chris
Publicado: (2016)

Predicting the evolution of antibiotic resistance
por: Schenk, Martijn F, et al.
Publicado: (2013)

Bacterial evolution of antibiotic hypersensitivity
por: Lázár, Viktória, et al.
Publicado: (2013)

The evolution of spectrum in antibiotics and bacteriocins
por: Palmer, Jacob D., et al.
Publicado: (2022)

Antibiotic collateral sensitivity is contingent on the repeatability of evolution
por: Nichol, Daniel, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_m08t32qdusm4cte506307egqoe