Effect of the sonic hedgehog inhibitor GDC-0449 on an in vitro isogenic cellular model simulating odontogenic keratocysts

Odontogenic keratocysts (OKCs) are common cystic lesions of odontogenic epithelial origin that can occur sporadically or in association with naevoid basal cell carcinoma syndrome (NBCCS). OKCs are locally aggressive, cause marked destruction of the jaw bones and have a propensity to recur. PTCH1 mut...

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Detalles Bibliográficos
Autores principales: Zhai, Jiemei, Zhang, Heyu, Zhang, Jianyun, Zhang, Ran, Hong, Yingying, Qu, Jiafei, Chen, Feng, Li, Tiejun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320367/
https://www.ncbi.nlm.nih.gov/pubmed/30610186
http://dx.doi.org/10.1038/s41368-018-0034-x

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