Targeting the proteostasis network in Huntington’s disease

Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder caused by a polyglutamine expansion mutation in the huntingtin protein. Expansions above 40 polyglutamine repeats are invariably fatal, following a symptomatic period characterised by choreiform movements, behavioural abno...

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Detalles Bibliográficos
Autores principales: Soares, Tânia R., Reis, Sara D., Pinho, Brígida R., Duchen, Michael R., Oliveira, Jorge M.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320389/
https://www.ncbi.nlm.nih.gov/pubmed/30502498
http://dx.doi.org/10.1016/j.arr.2018.11.006

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