In Vitro Cytotoxicity of Zinc Fructoborate, a Novel Zinc-Boron Active Natural Complex

In recent years, the role of zinc in biological systems has been a subject of intense research. Zinc is required for multiple metabolic processes as a structural, regulatory, or catalytic ion. The objective of this study, was to assess the toxicity profile of a newly synthesized zinc-boron molecule...

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Autores principales: OANCEA, C.N., CÎMPEAN, A., ION, R., NEAMŢU, J., BIŢĂ, A., SCOREI, I.R., NEAMŢU, A.S., ROGOVEANU, O.C., ZAHARIE, S.I., BIRKENMEIER, G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medical University Publishing House Craiova 2018
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320461/
https://www.ncbi.nlm.nih.gov/pubmed/30746157
http://dx.doi.org/10.12865/CHSJ.44.02.03
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author OANCEA, C.N.
CÎMPEAN, A.
ION, R.
NEAMŢU, J.
BIŢĂ, A.
SCOREI, I.R.
NEAMŢU, A.S.
ROGOVEANU, O.C.
ZAHARIE, S.I.
BIRKENMEIER, G.
author_facet OANCEA, C.N.
CÎMPEAN, A.
ION, R.
NEAMŢU, J.
BIŢĂ, A.
SCOREI, I.R.
NEAMŢU, A.S.
ROGOVEANU, O.C.
ZAHARIE, S.I.
BIRKENMEIER, G.
author_sort OANCEA, C.N.
collection PubMed
description In recent years, the role of zinc in biological systems has been a subject of intense research. Zinc is required for multiple metabolic processes as a structural, regulatory, or catalytic ion. The objective of this study, was to assess the toxicity profile of a newly synthesized zinc-boron molecule on cultured cells. Zinc fructoborate, at different levels of concentration, was tested for its impact on the Vero kidney cell line (ATCC® CCL-81™) using the MTT assay. The compound exhibited a low cytotoxic effect on the cell line. Thus, our study demonstrates that the zinc fructoborate could become a promising dietary supplement molecule.
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spelling pubmed-63204612019-02-11 In Vitro Cytotoxicity of Zinc Fructoborate, a Novel Zinc-Boron Active Natural Complex OANCEA, C.N. CÎMPEAN, A. ION, R. NEAMŢU, J. BIŢĂ, A. SCOREI, I.R. NEAMŢU, A.S. ROGOVEANU, O.C. ZAHARIE, S.I. BIRKENMEIER, G. Curr Health Sci J Original Paper In recent years, the role of zinc in biological systems has been a subject of intense research. Zinc is required for multiple metabolic processes as a structural, regulatory, or catalytic ion. The objective of this study, was to assess the toxicity profile of a newly synthesized zinc-boron molecule on cultured cells. Zinc fructoborate, at different levels of concentration, was tested for its impact on the Vero kidney cell line (ATCC® CCL-81™) using the MTT assay. The compound exhibited a low cytotoxic effect on the cell line. Thus, our study demonstrates that the zinc fructoborate could become a promising dietary supplement molecule. Medical University Publishing House Craiova 2018 2018-03-27 /pmc/articles/PMC6320461/ /pubmed/30746157 http://dx.doi.org/10.12865/CHSJ.44.02.03 Text en Copyright © 2018, Medical University Publishing House Craiova http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited.
spellingShingle Original Paper
OANCEA, C.N.
CÎMPEAN, A.
ION, R.
NEAMŢU, J.
BIŢĂ, A.
SCOREI, I.R.
NEAMŢU, A.S.
ROGOVEANU, O.C.
ZAHARIE, S.I.
BIRKENMEIER, G.
In Vitro Cytotoxicity of Zinc Fructoborate, a Novel Zinc-Boron Active Natural Complex
title In Vitro Cytotoxicity of Zinc Fructoborate, a Novel Zinc-Boron Active Natural Complex
title_full In Vitro Cytotoxicity of Zinc Fructoborate, a Novel Zinc-Boron Active Natural Complex
title_fullStr In Vitro Cytotoxicity of Zinc Fructoborate, a Novel Zinc-Boron Active Natural Complex
title_full_unstemmed In Vitro Cytotoxicity of Zinc Fructoborate, a Novel Zinc-Boron Active Natural Complex
title_short In Vitro Cytotoxicity of Zinc Fructoborate, a Novel Zinc-Boron Active Natural Complex
title_sort in vitro cytotoxicity of zinc fructoborate, a novel zinc-boron active natural complex
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320461/
https://www.ncbi.nlm.nih.gov/pubmed/30746157
http://dx.doi.org/10.12865/CHSJ.44.02.03
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