Immunoexpression of Transforming Growth Factor Beta 3 (TGFβ3) and Its Receptor Type III (TGFβRIII) in Basal Cell Carcinomas

ABSTRACT: Basal cell carcinomas (BCCs) are malignant tumors with particular biological prognosis and behavior, and the biomolecular investigation of these lesions can provide important therapeutic targets for epithelial neoplasia. In this study we analyzed the immunoexpression of transforming growth...

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Detalles Bibliográficos
Autores principales: FLORESCU, D., STEPAN, A.E., MĂRGĂRITESCU, C., SIMIONESCU, C.E., STEPAN, D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medical University Publishing House Craiova 2018
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320465/
https://www.ncbi.nlm.nih.gov/pubmed/30746165
http://dx.doi.org/10.12865/CHSJ.44.02.12
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author FLORESCU, D.
STEPAN, A.E.
MĂRGĂRITESCU, C.
SIMIONESCU, C.E.
STEPAN, D.
author_facet FLORESCU, D.
STEPAN, A.E.
MĂRGĂRITESCU, C.
SIMIONESCU, C.E.
STEPAN, D.
author_sort FLORESCU, D.
collection PubMed
description ABSTRACT: Basal cell carcinomas (BCCs) are malignant tumors with particular biological prognosis and behavior, and the biomolecular investigation of these lesions can provide important therapeutic targets for epithelial neoplasia. In this study we analyzed the immunoexpression of transforming growth factor beta 3 (TGFβ3) and its receptor type III (TGFβRIII) for 53 cases of BCC in relation to the main histopathological prognostic parameters. The results indicated statistically significant differences of TGFβ3 and TGFβRIII expression related to histological type and lesion stage, the both proteins being higher expressed in adenoid and morpheaform advanced stage tumors. In this study, TGFβ3 and TGFβRIII immunoexpression analysis indicated their utility for identifying aggressive BCCs with potential for tumor progression
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spelling pubmed-63204652019-02-11 Immunoexpression of Transforming Growth Factor Beta 3 (TGFβ3) and Its Receptor Type III (TGFβRIII) in Basal Cell Carcinomas FLORESCU, D. STEPAN, A.E. MĂRGĂRITESCU, C. SIMIONESCU, C.E. STEPAN, D. Curr Health Sci J Original Paper ABSTRACT: Basal cell carcinomas (BCCs) are malignant tumors with particular biological prognosis and behavior, and the biomolecular investigation of these lesions can provide important therapeutic targets for epithelial neoplasia. In this study we analyzed the immunoexpression of transforming growth factor beta 3 (TGFβ3) and its receptor type III (TGFβRIII) for 53 cases of BCC in relation to the main histopathological prognostic parameters. The results indicated statistically significant differences of TGFβ3 and TGFβRIII expression related to histological type and lesion stage, the both proteins being higher expressed in adenoid and morpheaform advanced stage tumors. In this study, TGFβ3 and TGFβRIII immunoexpression analysis indicated their utility for identifying aggressive BCCs with potential for tumor progression Medical University Publishing House Craiova 2018 2018-03-27 /pmc/articles/PMC6320465/ /pubmed/30746165 http://dx.doi.org/10.12865/CHSJ.44.02.12 Text en Copyright © 2018, Medical University Publishing House Craiova http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited.
spellingShingle Original Paper
FLORESCU, D.
STEPAN, A.E.
MĂRGĂRITESCU, C.
SIMIONESCU, C.E.
STEPAN, D.
Immunoexpression of Transforming Growth Factor Beta 3 (TGFβ3) and Its Receptor Type III (TGFβRIII) in Basal Cell Carcinomas
title Immunoexpression of Transforming Growth Factor Beta 3 (TGFβ3) and Its Receptor Type III (TGFβRIII) in Basal Cell Carcinomas
title_full Immunoexpression of Transforming Growth Factor Beta 3 (TGFβ3) and Its Receptor Type III (TGFβRIII) in Basal Cell Carcinomas
title_fullStr Immunoexpression of Transforming Growth Factor Beta 3 (TGFβ3) and Its Receptor Type III (TGFβRIII) in Basal Cell Carcinomas
title_full_unstemmed Immunoexpression of Transforming Growth Factor Beta 3 (TGFβ3) and Its Receptor Type III (TGFβRIII) in Basal Cell Carcinomas
title_short Immunoexpression of Transforming Growth Factor Beta 3 (TGFβ3) and Its Receptor Type III (TGFβRIII) in Basal Cell Carcinomas
title_sort immunoexpression of transforming growth factor beta 3 (tgfβ3) and its receptor type iii (tgfβriii) in basal cell carcinomas
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320465/
https://www.ncbi.nlm.nih.gov/pubmed/30746165
http://dx.doi.org/10.12865/CHSJ.44.02.12
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