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Serum calprotectin and ischemia modified albumin levels as markers of disease activity in Behçet’s disease

INTRODUCTION: Behçet’s disease (BD) is a complex multisystemic inflammatory disorder which is characterized by recurrent attacks of acute inflammation. As there is no universally recognized pathognomonic laboratory marker of BD, its diagnosis is still based on clinical findings. AIM: To evaluate the...

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Autores principales: Omma, Ahmet, Sandikci, Sevinc Can, Colak, Seda, Tecer, Duygu, Yucel, Cigdem, Ozbalkan, Zeynep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320477/
https://www.ncbi.nlm.nih.gov/pubmed/30618530
http://dx.doi.org/10.5114/pdia.2017.71269
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author Omma, Ahmet
Sandikci, Sevinc Can
Colak, Seda
Tecer, Duygu
Yucel, Cigdem
Ozbalkan, Zeynep
author_facet Omma, Ahmet
Sandikci, Sevinc Can
Colak, Seda
Tecer, Duygu
Yucel, Cigdem
Ozbalkan, Zeynep
author_sort Omma, Ahmet
collection PubMed
description INTRODUCTION: Behçet’s disease (BD) is a complex multisystemic inflammatory disorder which is characterized by recurrent attacks of acute inflammation. As there is no universally recognized pathognomonic laboratory marker of BD, its diagnosis is still based on clinical findings. AIM: To evaluate the role of calprotectin and ischemia modified albumin (IMA) as biomarkers in the assessment of disease activity of BD. MATERIAL AND METHODS: A total of 93 patients with BD and 62 age- and gender-matched healthy controls were included in the study. Disease activity was assessed with the BD Current Activity Form (BDCAF) score. Serum levels of calprotectin, high-sensitivity C-reactive protein (hsCRP) and IMA were measured in the patient and control groups. RESULTS: Serum levels of calprotectin, IMA and hsCRP in patients with BD were higher than those of the healthy control group (p < 0.001 for all). No correlations between calprotectin and IMA, hsCRP, erythrocyte sedimentation rate, CRP, or BDCAF score were found. CONCLUSIONS: As the calprotectin level are increased in BD patients, it could be a candidate biomarker which plays a role in BD pathogenesis.
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spelling pubmed-63204772019-01-07 Serum calprotectin and ischemia modified albumin levels as markers of disease activity in Behçet’s disease Omma, Ahmet Sandikci, Sevinc Can Colak, Seda Tecer, Duygu Yucel, Cigdem Ozbalkan, Zeynep Postepy Dermatol Alergol Original Paper INTRODUCTION: Behçet’s disease (BD) is a complex multisystemic inflammatory disorder which is characterized by recurrent attacks of acute inflammation. As there is no universally recognized pathognomonic laboratory marker of BD, its diagnosis is still based on clinical findings. AIM: To evaluate the role of calprotectin and ischemia modified albumin (IMA) as biomarkers in the assessment of disease activity of BD. MATERIAL AND METHODS: A total of 93 patients with BD and 62 age- and gender-matched healthy controls were included in the study. Disease activity was assessed with the BD Current Activity Form (BDCAF) score. Serum levels of calprotectin, high-sensitivity C-reactive protein (hsCRP) and IMA were measured in the patient and control groups. RESULTS: Serum levels of calprotectin, IMA and hsCRP in patients with BD were higher than those of the healthy control group (p < 0.001 for all). No correlations between calprotectin and IMA, hsCRP, erythrocyte sedimentation rate, CRP, or BDCAF score were found. CONCLUSIONS: As the calprotectin level are increased in BD patients, it could be a candidate biomarker which plays a role in BD pathogenesis. Termedia Publishing House 2018-11-13 2018-12 /pmc/articles/PMC6320477/ /pubmed/30618530 http://dx.doi.org/10.5114/pdia.2017.71269 Text en Copyright: © 2017 Termedia Sp. z o. o. http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Original Paper
Omma, Ahmet
Sandikci, Sevinc Can
Colak, Seda
Tecer, Duygu
Yucel, Cigdem
Ozbalkan, Zeynep
Serum calprotectin and ischemia modified albumin levels as markers of disease activity in Behçet’s disease
title Serum calprotectin and ischemia modified albumin levels as markers of disease activity in Behçet’s disease
title_full Serum calprotectin and ischemia modified albumin levels as markers of disease activity in Behçet’s disease
title_fullStr Serum calprotectin and ischemia modified albumin levels as markers of disease activity in Behçet’s disease
title_full_unstemmed Serum calprotectin and ischemia modified albumin levels as markers of disease activity in Behçet’s disease
title_short Serum calprotectin and ischemia modified albumin levels as markers of disease activity in Behçet’s disease
title_sort serum calprotectin and ischemia modified albumin levels as markers of disease activity in behçet’s disease
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320477/
https://www.ncbi.nlm.nih.gov/pubmed/30618530
http://dx.doi.org/10.5114/pdia.2017.71269
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