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Bax inhibitor 1 is a γ-secretase–independent presenilin-binding protein

Presenilin is the catalytic subunit of γ-secretase, a four-component intramembrane protease responsible for the generation of β-amyloid (Aβ) peptides. Over 200 Alzheimer’s disease-related mutations have been identified in presenilin 1 (PS1) and PS2. Here, we report that Bax-inhibitor 1 (BI1), an evo...

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Detalles Bibliográficos
Autores principales:	Wu, Shenjie, Song, Wenqi, Wong, Catherine C. L., Shi, Yigong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2019
Materias:	PNAS Plus
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320538/ https://www.ncbi.nlm.nih.gov/pubmed/30559186 http://dx.doi.org/10.1073/pnas.1810870116

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