Cargando…
Human induced pluripotent stem cell-derived MGE cell grafting after status epilepticus attenuates chronic epilepsy and comorbidities via synaptic integration
Medial ganglionic eminence (MGE)-like interneuron precursors derived from human induced pluripotent stem cells (hiPSCs) are ideal for developing patient-specific cell therapy in temporal lobe epilepsy (TLE). However, their efficacy for alleviating spontaneous recurrent seizures (SRS) or cognitive, m...
Autores principales: | Upadhya, Dinesh, Hattiangady, Bharathi, Castro, Olagide W., Shuai, Bing, Kodali, Maheedhar, Attaluri, Sahithi, Bates, Adrian, Dong, Yi, Zhang, Su-Chun, Prockop, Darwin J., Shetty, Ashok K. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320542/ https://www.ncbi.nlm.nih.gov/pubmed/30559206 http://dx.doi.org/10.1073/pnas.1814185115 |
Ejemplares similares
-
Chronic Oxidative Stress, Mitochondrial Dysfunction, Nrf2 Activation and Inflammation in the Hippocampus Accompany Heightened Systemic Inflammation and Oxidative Stress in an Animal Model of Gulf War Illness
por: Shetty, Geetha A., et al.
Publicado: (2017) -
A Model of Chronic Temporal Lobe Epilepsy Presenting Constantly Rhythmic and Robust Spontaneous Seizures, Co-morbidities and Hippocampal Neuropathology
por: Upadhya, Dinesh, et al.
Publicado: (2019) -
Intranasally Administered Human MSC-Derived Extracellular Vesicles Pervasively Incorporate into Neurons and Microglia in both Intact and Status Epilepticus Injured Forebrain
por: Kodali, Maheedhar, et al.
Publicado: (2019) -
Resveratrol for Easing Status Epilepticus Induced Brain Injury, Inflammation, Epileptogenesis, and Cognitive and Memory Dysfunction—Are We There Yet?
por: Castro, Olagide W., et al.
Publicado: (2017) -
Monosodium luminol reinstates redox homeostasis, improves cognition, mood and neurogenesis, and alleviates neuro- and systemic inflammation in a model of Gulf War Illness
por: Shetty, Ashok K., et al.
Publicado: (2019)