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Is a Low Incidence Rate of Ventilation Associated Pneumonia Associated with Lower Mortality? a Descriptive Longitudinal Study in Iran
BACKGROUND: Ventilator-Associated Pneumonia (VAP) is an important cause of morbidity and mortality in patients admitted to Intensive Care Unit (ICU). The current study conducted to estimate VAP incidence, attributable mortality and case fatality rate, cost, so related factors can affect the outcome...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Research Institute of Tuberculosis and Lung Disease
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320555/ https://www.ncbi.nlm.nih.gov/pubmed/30627182 |
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author | Chouhdari, Arezoo Shokouhi, Shervin Bashar, Farshid Rahimi Vahedian Azimi, Amir Shojaei, Seyed Pouzhia Fathi, Mohammad Goharani, Reza Sahraei, Zahra Hajiesmaeili, Mohammadreza |
author_facet | Chouhdari, Arezoo Shokouhi, Shervin Bashar, Farshid Rahimi Vahedian Azimi, Amir Shojaei, Seyed Pouzhia Fathi, Mohammad Goharani, Reza Sahraei, Zahra Hajiesmaeili, Mohammadreza |
author_sort | Chouhdari, Arezoo |
collection | PubMed |
description | BACKGROUND: Ventilator-Associated Pneumonia (VAP) is an important cause of morbidity and mortality in patients admitted to Intensive Care Unit (ICU). The current study conducted to estimate VAP incidence, attributable mortality and case fatality rate, cost, so related factors can affect the outcome in patients. MATERIALS AND METHODS: In this descriptive longitudinal study, demographic, clinical and para-clinical data were collected and attributable mortality and case fatality rate was estimated. Multivariable analysis was done to predict the possible risk factors on the outcome of VAP patients. Also, patients’ survival curve was plotted based on their length of ICU stay. Finally, the additional cost due to VAP in ICU was estimated. RESULTS: Totally, 8% ICU admissions were affected by VAP and 4% expired during the ICU stay. Further, the attributable mortality rate of VAP was high as compared with standard mortality rate. The most case fatality rate was for Acinetobacter sp. (n=17 60.7%). In multivariable logistic regression analysis, age greater than 40 years, more than 96 hours mechanical ventilation and uncontrolled diabetes mellitus were predictor factors of higher mortality. Inverse association between survival time and ICU length of stay was reported. Finally, the additional cost of VAP was estimated of about 700 US$ per patients. CONCLUSION: According to the results, strategies to prevent mortality by reducing the duration of ventilation and ICU length of stay should be performed. Also, mandatory fees for the family and the healthcare system should be planned. |
format | Online Article Text |
id | pubmed-6320555 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | National Research Institute of Tuberculosis and Lung Disease |
record_format | MEDLINE/PubMed |
spelling | pubmed-63205552019-01-09 Is a Low Incidence Rate of Ventilation Associated Pneumonia Associated with Lower Mortality? a Descriptive Longitudinal Study in Iran Chouhdari, Arezoo Shokouhi, Shervin Bashar, Farshid Rahimi Vahedian Azimi, Amir Shojaei, Seyed Pouzhia Fathi, Mohammad Goharani, Reza Sahraei, Zahra Hajiesmaeili, Mohammadreza Tanaffos Original Article BACKGROUND: Ventilator-Associated Pneumonia (VAP) is an important cause of morbidity and mortality in patients admitted to Intensive Care Unit (ICU). The current study conducted to estimate VAP incidence, attributable mortality and case fatality rate, cost, so related factors can affect the outcome in patients. MATERIALS AND METHODS: In this descriptive longitudinal study, demographic, clinical and para-clinical data were collected and attributable mortality and case fatality rate was estimated. Multivariable analysis was done to predict the possible risk factors on the outcome of VAP patients. Also, patients’ survival curve was plotted based on their length of ICU stay. Finally, the additional cost due to VAP in ICU was estimated. RESULTS: Totally, 8% ICU admissions were affected by VAP and 4% expired during the ICU stay. Further, the attributable mortality rate of VAP was high as compared with standard mortality rate. The most case fatality rate was for Acinetobacter sp. (n=17 60.7%). In multivariable logistic regression analysis, age greater than 40 years, more than 96 hours mechanical ventilation and uncontrolled diabetes mellitus were predictor factors of higher mortality. Inverse association between survival time and ICU length of stay was reported. Finally, the additional cost of VAP was estimated of about 700 US$ per patients. CONCLUSION: According to the results, strategies to prevent mortality by reducing the duration of ventilation and ICU length of stay should be performed. Also, mandatory fees for the family and the healthcare system should be planned. National Research Institute of Tuberculosis and Lung Disease 2018-02 /pmc/articles/PMC6320555/ /pubmed/30627182 Text en Copyright© 2018 National Research Institute of Tuberculosis and Lung Disease http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Chouhdari, Arezoo Shokouhi, Shervin Bashar, Farshid Rahimi Vahedian Azimi, Amir Shojaei, Seyed Pouzhia Fathi, Mohammad Goharani, Reza Sahraei, Zahra Hajiesmaeili, Mohammadreza Is a Low Incidence Rate of Ventilation Associated Pneumonia Associated with Lower Mortality? a Descriptive Longitudinal Study in Iran |
title | Is a Low Incidence Rate of Ventilation Associated Pneumonia Associated with Lower Mortality? a Descriptive Longitudinal Study in Iran |
title_full | Is a Low Incidence Rate of Ventilation Associated Pneumonia Associated with Lower Mortality? a Descriptive Longitudinal Study in Iran |
title_fullStr | Is a Low Incidence Rate of Ventilation Associated Pneumonia Associated with Lower Mortality? a Descriptive Longitudinal Study in Iran |
title_full_unstemmed | Is a Low Incidence Rate of Ventilation Associated Pneumonia Associated with Lower Mortality? a Descriptive Longitudinal Study in Iran |
title_short | Is a Low Incidence Rate of Ventilation Associated Pneumonia Associated with Lower Mortality? a Descriptive Longitudinal Study in Iran |
title_sort | is a low incidence rate of ventilation associated pneumonia associated with lower mortality? a descriptive longitudinal study in iran |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320555/ https://www.ncbi.nlm.nih.gov/pubmed/30627182 |
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