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Drosophila Gut—A Nexus Between Dietary Restriction and Lifespan

Aging is often defined as the accumulation of damage at the molecular and cellular levels which, over time, results in marked physiological impairments throughout the organism. Dietary restriction (DR) has been recognized as one of the strongest lifespan extending therapies observed in a wide array...

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Detalles Bibliográficos
Autores principales: Lian, Ting, Wu, Qi, Hodge, Brian A., Wilson, Kenneth A., Yu, Guixiang, Yang, Mingyao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320777/
https://www.ncbi.nlm.nih.gov/pubmed/30501099
http://dx.doi.org/10.3390/ijms19123810
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author Lian, Ting
Wu, Qi
Hodge, Brian A.
Wilson, Kenneth A.
Yu, Guixiang
Yang, Mingyao
author_facet Lian, Ting
Wu, Qi
Hodge, Brian A.
Wilson, Kenneth A.
Yu, Guixiang
Yang, Mingyao
author_sort Lian, Ting
collection PubMed
description Aging is often defined as the accumulation of damage at the molecular and cellular levels which, over time, results in marked physiological impairments throughout the organism. Dietary restriction (DR) has been recognized as one of the strongest lifespan extending therapies observed in a wide array of organisms. Recent studies aimed at elucidating how DR promotes healthy aging have demonstrated a vital role of the digestive tract in mediating the beneficial effects of DR. Here, we review how dietary restriction influences gut metabolic homeostasis and immune function. Our discussion is focused on studies of the Drosophila digestive tract, where we describe in detail the potential mechanisms in which DR enhances maintenance of the intestinal epithelial barrier, up-regulates lipid metabolic processes, and improves the ability of the gut to deal with damage or stress. We also examine evidence of a tissue-tissue crosstalk between gut and neighboring organs including brain and fat body. Taken together, we argue that the Drosophila gut plays a critical role in DR-mediated lifespan extension.
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spelling pubmed-63207772019-01-07 Drosophila Gut—A Nexus Between Dietary Restriction and Lifespan Lian, Ting Wu, Qi Hodge, Brian A. Wilson, Kenneth A. Yu, Guixiang Yang, Mingyao Int J Mol Sci Review Aging is often defined as the accumulation of damage at the molecular and cellular levels which, over time, results in marked physiological impairments throughout the organism. Dietary restriction (DR) has been recognized as one of the strongest lifespan extending therapies observed in a wide array of organisms. Recent studies aimed at elucidating how DR promotes healthy aging have demonstrated a vital role of the digestive tract in mediating the beneficial effects of DR. Here, we review how dietary restriction influences gut metabolic homeostasis and immune function. Our discussion is focused on studies of the Drosophila digestive tract, where we describe in detail the potential mechanisms in which DR enhances maintenance of the intestinal epithelial barrier, up-regulates lipid metabolic processes, and improves the ability of the gut to deal with damage or stress. We also examine evidence of a tissue-tissue crosstalk between gut and neighboring organs including brain and fat body. Taken together, we argue that the Drosophila gut plays a critical role in DR-mediated lifespan extension. MDPI 2018-11-29 /pmc/articles/PMC6320777/ /pubmed/30501099 http://dx.doi.org/10.3390/ijms19123810 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lian, Ting
Wu, Qi
Hodge, Brian A.
Wilson, Kenneth A.
Yu, Guixiang
Yang, Mingyao
Drosophila Gut—A Nexus Between Dietary Restriction and Lifespan
title Drosophila Gut—A Nexus Between Dietary Restriction and Lifespan
title_full Drosophila Gut—A Nexus Between Dietary Restriction and Lifespan
title_fullStr Drosophila Gut—A Nexus Between Dietary Restriction and Lifespan
title_full_unstemmed Drosophila Gut—A Nexus Between Dietary Restriction and Lifespan
title_short Drosophila Gut—A Nexus Between Dietary Restriction and Lifespan
title_sort drosophila gut—a nexus between dietary restriction and lifespan
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320777/
https://www.ncbi.nlm.nih.gov/pubmed/30501099
http://dx.doi.org/10.3390/ijms19123810
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