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Drosophila Gut—A Nexus Between Dietary Restriction and Lifespan
Aging is often defined as the accumulation of damage at the molecular and cellular levels which, over time, results in marked physiological impairments throughout the organism. Dietary restriction (DR) has been recognized as one of the strongest lifespan extending therapies observed in a wide array...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320777/ https://www.ncbi.nlm.nih.gov/pubmed/30501099 http://dx.doi.org/10.3390/ijms19123810 |
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author | Lian, Ting Wu, Qi Hodge, Brian A. Wilson, Kenneth A. Yu, Guixiang Yang, Mingyao |
author_facet | Lian, Ting Wu, Qi Hodge, Brian A. Wilson, Kenneth A. Yu, Guixiang Yang, Mingyao |
author_sort | Lian, Ting |
collection | PubMed |
description | Aging is often defined as the accumulation of damage at the molecular and cellular levels which, over time, results in marked physiological impairments throughout the organism. Dietary restriction (DR) has been recognized as one of the strongest lifespan extending therapies observed in a wide array of organisms. Recent studies aimed at elucidating how DR promotes healthy aging have demonstrated a vital role of the digestive tract in mediating the beneficial effects of DR. Here, we review how dietary restriction influences gut metabolic homeostasis and immune function. Our discussion is focused on studies of the Drosophila digestive tract, where we describe in detail the potential mechanisms in which DR enhances maintenance of the intestinal epithelial barrier, up-regulates lipid metabolic processes, and improves the ability of the gut to deal with damage or stress. We also examine evidence of a tissue-tissue crosstalk between gut and neighboring organs including brain and fat body. Taken together, we argue that the Drosophila gut plays a critical role in DR-mediated lifespan extension. |
format | Online Article Text |
id | pubmed-6320777 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63207772019-01-07 Drosophila Gut—A Nexus Between Dietary Restriction and Lifespan Lian, Ting Wu, Qi Hodge, Brian A. Wilson, Kenneth A. Yu, Guixiang Yang, Mingyao Int J Mol Sci Review Aging is often defined as the accumulation of damage at the molecular and cellular levels which, over time, results in marked physiological impairments throughout the organism. Dietary restriction (DR) has been recognized as one of the strongest lifespan extending therapies observed in a wide array of organisms. Recent studies aimed at elucidating how DR promotes healthy aging have demonstrated a vital role of the digestive tract in mediating the beneficial effects of DR. Here, we review how dietary restriction influences gut metabolic homeostasis and immune function. Our discussion is focused on studies of the Drosophila digestive tract, where we describe in detail the potential mechanisms in which DR enhances maintenance of the intestinal epithelial barrier, up-regulates lipid metabolic processes, and improves the ability of the gut to deal with damage or stress. We also examine evidence of a tissue-tissue crosstalk between gut and neighboring organs including brain and fat body. Taken together, we argue that the Drosophila gut plays a critical role in DR-mediated lifespan extension. MDPI 2018-11-29 /pmc/articles/PMC6320777/ /pubmed/30501099 http://dx.doi.org/10.3390/ijms19123810 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lian, Ting Wu, Qi Hodge, Brian A. Wilson, Kenneth A. Yu, Guixiang Yang, Mingyao Drosophila Gut—A Nexus Between Dietary Restriction and Lifespan |
title | Drosophila Gut—A Nexus Between Dietary Restriction and Lifespan |
title_full | Drosophila Gut—A Nexus Between Dietary Restriction and Lifespan |
title_fullStr | Drosophila Gut—A Nexus Between Dietary Restriction and Lifespan |
title_full_unstemmed | Drosophila Gut—A Nexus Between Dietary Restriction and Lifespan |
title_short | Drosophila Gut—A Nexus Between Dietary Restriction and Lifespan |
title_sort | drosophila gut—a nexus between dietary restriction and lifespan |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320777/ https://www.ncbi.nlm.nih.gov/pubmed/30501099 http://dx.doi.org/10.3390/ijms19123810 |
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