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Importance of Binding Affinity for the Activity of a Metallodendritic Chemical Nuclease

A family of bis(2-pyridyl)amino-modified poly(amidoamine) dendrimer Cu complexes was prepared, and their chemical nuclease activities and binding affinity (K(b)) levels for DNA plasmid were investigated. The K(b) values of the G2 to G6 apodendrimers for DNA plasmid were found to be 7.4, 23, 48, 70,...

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Detalles Bibliográficos
Autores principales:	Tang, Yi-Hsuan, Hsu, Sodio C. N., Chen, Po-Yu, Liou, Si-ting, Chen, Hui-Ting, Wu, Carol Hsin-Yi, Kao, Chai-Lin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320806/ https://www.ncbi.nlm.nih.gov/pubmed/30513860 http://dx.doi.org/10.3390/pharmaceutics10040258

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