Pharmacological Inhibition of LSD1 for Cancer Treatment

Lysine-specific demethylase 1A (LSD1, also named KDM1A) is a demethylase that can remove methyl groups from histones H3K4me1/2 and H3K9me1/2. It is aberrantly expressed in many cancers, where it impedes differentiation and contributes to cancer cell proliferation, cell metastasis and invasiveness, a...

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Detalles Bibliográficos
Autores principales: Yang, Guan-Jun, Lei, Pui-Man, Wong, Suk-Yu, Ma, Dik-Lung, Leung, Chung-Hang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320820/
https://www.ncbi.nlm.nih.gov/pubmed/30518104
http://dx.doi.org/10.3390/molecules23123194

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320820/
https://www.ncbi.nlm.nih.gov/pubmed/30518104
http://dx.doi.org/10.3390/molecules23123194

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