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In Vitro Immune Organs-on-Chip for Drug Development: A Review
The current drug development practice lacks reliable and sensitive techniques to evaluate the immunotoxicity of drug candidates, i.e., their effect on the human immune system. This, in part, has resulted in a high attrition rate for novel drugs candidates. Organ-on-chip devices have emerged as key t...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320867/ https://www.ncbi.nlm.nih.gov/pubmed/30558264 http://dx.doi.org/10.3390/pharmaceutics10040278 |
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author | Shanti, Aya Teo, Jeremy Stefanini, Cesare |
author_facet | Shanti, Aya Teo, Jeremy Stefanini, Cesare |
author_sort | Shanti, Aya |
collection | PubMed |
description | The current drug development practice lacks reliable and sensitive techniques to evaluate the immunotoxicity of drug candidates, i.e., their effect on the human immune system. This, in part, has resulted in a high attrition rate for novel drugs candidates. Organ-on-chip devices have emerged as key tools that permit the study of human physiology in controlled in vivo simulating environments. Furthermore, there has been a growing interest in developing the so called “body-on-chip” devices to better predict the systemic effects of drug candidates. This review describes existing biomimetic immune organs-on-chip, highlights their physiological relevance to drug development and discovery and emphasizes the need for developing comprehensive immune system-on-chip models. Such immune models can enhance the performance of novel drug candidates during clinical trials and contribute to reducing the high attrition rate as well as the high cost associated with drug development. |
format | Online Article Text |
id | pubmed-6320867 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63208672019-01-11 In Vitro Immune Organs-on-Chip for Drug Development: A Review Shanti, Aya Teo, Jeremy Stefanini, Cesare Pharmaceutics Review The current drug development practice lacks reliable and sensitive techniques to evaluate the immunotoxicity of drug candidates, i.e., their effect on the human immune system. This, in part, has resulted in a high attrition rate for novel drugs candidates. Organ-on-chip devices have emerged as key tools that permit the study of human physiology in controlled in vivo simulating environments. Furthermore, there has been a growing interest in developing the so called “body-on-chip” devices to better predict the systemic effects of drug candidates. This review describes existing biomimetic immune organs-on-chip, highlights their physiological relevance to drug development and discovery and emphasizes the need for developing comprehensive immune system-on-chip models. Such immune models can enhance the performance of novel drug candidates during clinical trials and contribute to reducing the high attrition rate as well as the high cost associated with drug development. MDPI 2018-12-15 /pmc/articles/PMC6320867/ /pubmed/30558264 http://dx.doi.org/10.3390/pharmaceutics10040278 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Shanti, Aya Teo, Jeremy Stefanini, Cesare In Vitro Immune Organs-on-Chip for Drug Development: A Review |
title | In Vitro Immune Organs-on-Chip for Drug Development: A Review |
title_full | In Vitro Immune Organs-on-Chip for Drug Development: A Review |
title_fullStr | In Vitro Immune Organs-on-Chip for Drug Development: A Review |
title_full_unstemmed | In Vitro Immune Organs-on-Chip for Drug Development: A Review |
title_short | In Vitro Immune Organs-on-Chip for Drug Development: A Review |
title_sort | in vitro immune organs-on-chip for drug development: a review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320867/ https://www.ncbi.nlm.nih.gov/pubmed/30558264 http://dx.doi.org/10.3390/pharmaceutics10040278 |
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