Cargando…

In Vitro Immune Organs-on-Chip for Drug Development: A Review

The current drug development practice lacks reliable and sensitive techniques to evaluate the immunotoxicity of drug candidates, i.e., their effect on the human immune system. This, in part, has resulted in a high attrition rate for novel drugs candidates. Organ-on-chip devices have emerged as key t...

Descripción completa

Detalles Bibliográficos
Autores principales: Shanti, Aya, Teo, Jeremy, Stefanini, Cesare
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320867/
https://www.ncbi.nlm.nih.gov/pubmed/30558264
http://dx.doi.org/10.3390/pharmaceutics10040278
_version_ 1783385306962067456
author Shanti, Aya
Teo, Jeremy
Stefanini, Cesare
author_facet Shanti, Aya
Teo, Jeremy
Stefanini, Cesare
author_sort Shanti, Aya
collection PubMed
description The current drug development practice lacks reliable and sensitive techniques to evaluate the immunotoxicity of drug candidates, i.e., their effect on the human immune system. This, in part, has resulted in a high attrition rate for novel drugs candidates. Organ-on-chip devices have emerged as key tools that permit the study of human physiology in controlled in vivo simulating environments. Furthermore, there has been a growing interest in developing the so called “body-on-chip” devices to better predict the systemic effects of drug candidates. This review describes existing biomimetic immune organs-on-chip, highlights their physiological relevance to drug development and discovery and emphasizes the need for developing comprehensive immune system-on-chip models. Such immune models can enhance the performance of novel drug candidates during clinical trials and contribute to reducing the high attrition rate as well as the high cost associated with drug development.
format Online
Article
Text
id pubmed-6320867
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-63208672019-01-11 In Vitro Immune Organs-on-Chip for Drug Development: A Review Shanti, Aya Teo, Jeremy Stefanini, Cesare Pharmaceutics Review The current drug development practice lacks reliable and sensitive techniques to evaluate the immunotoxicity of drug candidates, i.e., their effect on the human immune system. This, in part, has resulted in a high attrition rate for novel drugs candidates. Organ-on-chip devices have emerged as key tools that permit the study of human physiology in controlled in vivo simulating environments. Furthermore, there has been a growing interest in developing the so called “body-on-chip” devices to better predict the systemic effects of drug candidates. This review describes existing biomimetic immune organs-on-chip, highlights their physiological relevance to drug development and discovery and emphasizes the need for developing comprehensive immune system-on-chip models. Such immune models can enhance the performance of novel drug candidates during clinical trials and contribute to reducing the high attrition rate as well as the high cost associated with drug development. MDPI 2018-12-15 /pmc/articles/PMC6320867/ /pubmed/30558264 http://dx.doi.org/10.3390/pharmaceutics10040278 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Shanti, Aya
Teo, Jeremy
Stefanini, Cesare
In Vitro Immune Organs-on-Chip for Drug Development: A Review
title In Vitro Immune Organs-on-Chip for Drug Development: A Review
title_full In Vitro Immune Organs-on-Chip for Drug Development: A Review
title_fullStr In Vitro Immune Organs-on-Chip for Drug Development: A Review
title_full_unstemmed In Vitro Immune Organs-on-Chip for Drug Development: A Review
title_short In Vitro Immune Organs-on-Chip for Drug Development: A Review
title_sort in vitro immune organs-on-chip for drug development: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320867/
https://www.ncbi.nlm.nih.gov/pubmed/30558264
http://dx.doi.org/10.3390/pharmaceutics10040278
work_keys_str_mv AT shantiaya invitroimmuneorgansonchipfordrugdevelopmentareview
AT teojeremy invitroimmuneorgansonchipfordrugdevelopmentareview
AT stefaninicesare invitroimmuneorgansonchipfordrugdevelopmentareview