Discovery of a Natural Syk Inhibitor from Chinese Medicine through a Docking-Based Virtual Screening and Biological Assay Study

Spleen tyrosine kinase (Syk) is a critical target protein for treating immunoreceptor signalling-mediated allergies. In this study, a virtual screening of an in-house Chinese medicine database followed by biological assays was carried out to identify novel Syk inhibitors. A molecular docking method...

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Detalles Bibliográficos
Autores principales: Wang, Xing, Guo, Junfang, Ning, Zhongqi, Wu, Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320911/
https://www.ncbi.nlm.nih.gov/pubmed/30487406
http://dx.doi.org/10.3390/molecules23123114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320911/
https://www.ncbi.nlm.nih.gov/pubmed/30487406
http://dx.doi.org/10.3390/molecules23123114

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