Native Quercetin as a Chloride Receptor in an Organic Solvent

The binding properties of quercetin toward chloride anions were investigated by means of (1)H-NMR, (13)C-NMR, and electrospray ionization mass spectrometry (ESI-MS) measurements, as well as computational calculations. The results indicate that quercetin behaves primarily as a ditopic receptor with t...

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Detalles Bibliográficos
Autores principales: Abdi Bellau, Mohamed Lamin, Bortolini, Olga, Fantin, Giancarlo, Fogagnolo, Marco, Ragno, Daniele, Delso, Ignacio, Merino, Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320934/
https://www.ncbi.nlm.nih.gov/pubmed/30572599
http://dx.doi.org/10.3390/molecules23123366
Descripción
Sumario:The binding properties of quercetin toward chloride anions were investigated by means of (1)H-NMR, (13)C-NMR, and electrospray ionization mass spectrometry (ESI-MS) measurements, as well as computational calculations. The results indicate that quercetin behaves primarily as a ditopic receptor with the binding site of the B ring that exhibits stronger chloride affinity compared to the A ring. However, these sites are stronger receptors than those of catechol and resorcinol because of their conjugation with the carbonyl group located on the C ring. The 1:1 and 1:2 complexation of this flavonoid with Cl(−) was also supported by ESI mass spectrometry.

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