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Brain Distribution and Metabolism of Flupirtine, a Nonopioid Analgesic Drug with Antiseizure Effects, in Neonatal Rats

Flupirtine, a nonopioid analgesic drug, is effective in treating neonatal seizures. However, its brain delivery and pharmacokinetics are unknown in neonatal mammals. The purpose of this study was to determine the pharmacokinetics of flupirtine and the formation of its active metabolite D-13223 in va...

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Detalles Bibliográficos
Autores principales:	Patil, Madhoosudan A., Matter, Brock A., Raol, Yogendra H., Bourne, David W. A., Kelley, Ryan A., Kompella, Uday B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320943/ https://www.ncbi.nlm.nih.gov/pubmed/30558371 http://dx.doi.org/10.3390/pharmaceutics10040281

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