Fusaproliferin, a Fungal Mycotoxin, Shows Cytotoxicity against Pancreatic Cancer Cell Lines

As a part of our ongoing research on endophytic fungi, we have isolated a sesterterpene mycotoxin, fusaproliferin (FUS), from a Fusarium solani strain, which is associated with the plant Aglaonema hookerianum Schott. FUS showed rapid and sub-micromolar IC(50) against pancreatic cancer cell lines. Ti...

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Autores principales: Hoque, Nazia, Hasan, Choudhury Mahmood, Rana, Md. Sohel, Varsha, Amrit, Sohrab, Md. Hossain, Rahman, Khondaker Miraz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320971/
https://www.ncbi.nlm.nih.gov/pubmed/30545017
http://dx.doi.org/10.3390/molecules23123288
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author Hoque, Nazia
Hasan, Choudhury Mahmood
Rana, Md. Sohel
Varsha, Amrit
Sohrab, Md. Hossain
Rahman, Khondaker Miraz
author_facet Hoque, Nazia
Hasan, Choudhury Mahmood
Rana, Md. Sohel
Varsha, Amrit
Sohrab, Md. Hossain
Rahman, Khondaker Miraz
author_sort Hoque, Nazia
collection PubMed
description As a part of our ongoing research on endophytic fungi, we have isolated a sesterterpene mycotoxin, fusaproliferin (FUS), from a Fusarium solani strain, which is associated with the plant Aglaonema hookerianum Schott. FUS showed rapid and sub-micromolar IC(50) against pancreatic cancer cell lines. Time-dependent survival analysis and microscopy imaging showed rapid morphological changes in cancer cell lines 4 h after incubation with FUS. This provides a new chemical scaffold that can be further developed to obtain more potent synthetic agents against pancreatic cancer.
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spelling pubmed-63209712019-01-14 Fusaproliferin, a Fungal Mycotoxin, Shows Cytotoxicity against Pancreatic Cancer Cell Lines Hoque, Nazia Hasan, Choudhury Mahmood Rana, Md. Sohel Varsha, Amrit Sohrab, Md. Hossain Rahman, Khondaker Miraz Molecules Article As a part of our ongoing research on endophytic fungi, we have isolated a sesterterpene mycotoxin, fusaproliferin (FUS), from a Fusarium solani strain, which is associated with the plant Aglaonema hookerianum Schott. FUS showed rapid and sub-micromolar IC(50) against pancreatic cancer cell lines. Time-dependent survival analysis and microscopy imaging showed rapid morphological changes in cancer cell lines 4 h after incubation with FUS. This provides a new chemical scaffold that can be further developed to obtain more potent synthetic agents against pancreatic cancer. MDPI 2018-12-11 /pmc/articles/PMC6320971/ /pubmed/30545017 http://dx.doi.org/10.3390/molecules23123288 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hoque, Nazia
Hasan, Choudhury Mahmood
Rana, Md. Sohel
Varsha, Amrit
Sohrab, Md. Hossain
Rahman, Khondaker Miraz
Fusaproliferin, a Fungal Mycotoxin, Shows Cytotoxicity against Pancreatic Cancer Cell Lines
title Fusaproliferin, a Fungal Mycotoxin, Shows Cytotoxicity against Pancreatic Cancer Cell Lines
title_full Fusaproliferin, a Fungal Mycotoxin, Shows Cytotoxicity against Pancreatic Cancer Cell Lines
title_fullStr Fusaproliferin, a Fungal Mycotoxin, Shows Cytotoxicity against Pancreatic Cancer Cell Lines
title_full_unstemmed Fusaproliferin, a Fungal Mycotoxin, Shows Cytotoxicity against Pancreatic Cancer Cell Lines
title_short Fusaproliferin, a Fungal Mycotoxin, Shows Cytotoxicity against Pancreatic Cancer Cell Lines
title_sort fusaproliferin, a fungal mycotoxin, shows cytotoxicity against pancreatic cancer cell lines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320971/
https://www.ncbi.nlm.nih.gov/pubmed/30545017
http://dx.doi.org/10.3390/molecules23123288
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