Function and Interactions of ERCC1-XPF in DNA Damage Response

Numerous proteins are involved in the multiple pathways of the DNA damage response network and play a key role to protect the genome from the wide variety of damages that can occur to DNA. An example of this is the structure-specific endonuclease ERCC1-XPF. This heterodimeric complex is in particula...

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Autores principales: Faridounnia, Maryam, Folkers, Gert E., Boelens, Rolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320978/
https://www.ncbi.nlm.nih.gov/pubmed/30563071
http://dx.doi.org/10.3390/molecules23123205
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author Faridounnia, Maryam
Folkers, Gert E.
Boelens, Rolf
author_facet Faridounnia, Maryam
Folkers, Gert E.
Boelens, Rolf
author_sort Faridounnia, Maryam
collection PubMed
description Numerous proteins are involved in the multiple pathways of the DNA damage response network and play a key role to protect the genome from the wide variety of damages that can occur to DNA. An example of this is the structure-specific endonuclease ERCC1-XPF. This heterodimeric complex is in particular involved in nucleotide excision repair (NER), but also in double strand break repair and interstrand cross-link repair pathways. Here we review the function of ERCC1-XPF in various DNA repair pathways and discuss human disorders associated with ERCC1-XPF deficiency. We also overview our molecular and structural understanding of XPF-ERCC1.
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spelling pubmed-63209782019-01-14 Function and Interactions of ERCC1-XPF in DNA Damage Response Faridounnia, Maryam Folkers, Gert E. Boelens, Rolf Molecules Review Numerous proteins are involved in the multiple pathways of the DNA damage response network and play a key role to protect the genome from the wide variety of damages that can occur to DNA. An example of this is the structure-specific endonuclease ERCC1-XPF. This heterodimeric complex is in particular involved in nucleotide excision repair (NER), but also in double strand break repair and interstrand cross-link repair pathways. Here we review the function of ERCC1-XPF in various DNA repair pathways and discuss human disorders associated with ERCC1-XPF deficiency. We also overview our molecular and structural understanding of XPF-ERCC1. MDPI 2018-12-05 /pmc/articles/PMC6320978/ /pubmed/30563071 http://dx.doi.org/10.3390/molecules23123205 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Faridounnia, Maryam
Folkers, Gert E.
Boelens, Rolf
Function and Interactions of ERCC1-XPF in DNA Damage Response
title Function and Interactions of ERCC1-XPF in DNA Damage Response
title_full Function and Interactions of ERCC1-XPF in DNA Damage Response
title_fullStr Function and Interactions of ERCC1-XPF in DNA Damage Response
title_full_unstemmed Function and Interactions of ERCC1-XPF in DNA Damage Response
title_short Function and Interactions of ERCC1-XPF in DNA Damage Response
title_sort function and interactions of ercc1-xpf in dna damage response
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320978/
https://www.ncbi.nlm.nih.gov/pubmed/30563071
http://dx.doi.org/10.3390/molecules23123205
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