Cargando…

Function and Interactions of ERCC1-XPF in DNA Damage Response

Numerous proteins are involved in the multiple pathways of the DNA damage response network and play a key role to protect the genome from the wide variety of damages that can occur to DNA. An example of this is the structure-specific endonuclease ERCC1-XPF. This heterodimeric complex is in particula...

Descripción completa

Detalles Bibliográficos
Autores principales:	Faridounnia, Maryam, Folkers, Gert E., Boelens, Rolf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320978/ https://www.ncbi.nlm.nih.gov/pubmed/30563071 http://dx.doi.org/10.3390/molecules23123205

Ejemplares similares

XPF–ERCC1: Linchpin of DNA crosslink repair
por: McHugh, Peter J.
Publicado: (2020)

USP45 deubiquitylase controls ERCC1–XPF endonuclease-mediated DNA damage responses
por: Perez-Oliva, Ana B, et al.
Publicado: (2015)

Acetylation of XPF by TIP60 facilitates XPF-ERCC1 complex assembly and activation
por: Wang, Jiajia, et al.
Publicado: (2020)

Analysis of the XPA and ssDNA-binding surfaces on the central domain of human ERCC1 reveals evidence for subfunctionalization
por: Tripsianes, Konstantinos, et al.
Publicado: (2007)

Association of ERCC1 and XPF polymorphisms with pediatric glioma susceptibility
por: Chen, Yongping, et al.
Publicado: (2023)

RPA activates the XPF‐ERCC1 endonuclease to initiate processing of DNA interstrand crosslinks
por: Abdullah, Ummi B, et al.
Publicado: (2017)

ERCC1–XPF targeting to psoralen–DNA crosslinks depends on XPA and FANCD2
por: Sabatella, Mariangela, et al.
Publicado: (2019)

Expression and Clinical Significance of ERCC1 and XPF in Human Hepatocellular Carcinoma
por: Liao, Xiaoli, et al.
Publicado: (2020)

Functional Polymorphisms at ERCC1/XPF Genes Confer Neuroblastoma Risk in Chinese Children
por: Zhuo, Zhen-Jian, et al.
Publicado: (2018)

Mislocalization of XPF-ERCC1 Nuclease Contributes to Reduced DNA Repair in XP-F Patients
por: Ahmad, Anwaar, et al.
Publicado: (2010)

ERCC1/XPF Is Important for Repair of DNA Double-Strand Breaks Containing Secondary Structures
por: Li, Shibo, et al.
Publicado: (2019)

The splicing factor XAB2 interacts with ERCC1-XPF and XPG for R-loop processing
por: Goulielmaki, Evi, et al.
Publicado: (2021)

Chemical Incorporation of Chain-Terminating Nucleoside Analogs as 3′-Blocking DNA Damage and Their Removal by Human ERCC1-XPF Endonuclease
por: Yamamoto, Junpei, et al.
Publicado: (2016)

Impact of ERCC1, XPF and DNA Polymerase β Expression on Platinum Response in Patient-Derived Ovarian Cancer Xenografts
por: Guffanti, Federica, et al.
Publicado: (2020)

ERCC1/XPF Protects Short Telomeres from Homologous Recombination in Arabidopsis thaliana
por: Vannier, Jean-Baptiste, et al.
Publicado: (2009)

Polymorphisms in ERCC1 and XPF Genes and Risk of Gastric Cancer in an Eastern Chinese Population
por: He, Jing, et al.
Publicado: (2012)

Poly(ADP-ribose) polymerase and XPF–ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells
por: Zhang, Yong-Wei, et al.
Publicado: (2011)

DNA repair endonuclease ERCC1–XPF as a novel therapeutic target to overcome chemoresistance in cancer therapy
por: McNeil, Ewan M., et al.
Publicado: (2012)

Computational Characterization of Small Molecules Binding to the Human XPF Active Site and Virtual Screening to Identify Potential New DNA Repair Inhibitors Targeting the ERCC1-XPF Endonuclease
por: Gentile, Francesco, et al.
Publicado: (2018)

Recruitment and positioning determine the specific role of the XPF‐ERCC1 endonuclease in interstrand crosslink repair
por: Klein Douwel, Daisy, et al.
Publicado: (2017)

Fluorescence-based incision assay for human XPF–ERCC1 activity identifies important elements of DNA junction recognition
por: Bowles, Maureen, et al.
Publicado: (2012)

Mouse SLX4 Is a Tumor Suppressor that Stimulates the Activity of the Nuclease XPF-ERCC1 in DNA Crosslink Repair
por: Hodskinson, Michael R.G., et al.
Publicado: (2014)

Identification of small molecule inhibitors of ERCC1-XPF that inhibit DNA repair and potentiate cisplatin efficacy in cancer cells
por: Arora, Sanjeevani, et al.
Publicado: (2016)

The ERCC1/XPF endonuclease is required for completion of homologous recombination at DNA replication forks stalled by inter-strand cross-links
por: Al-Minawi, Ali Z., et al.
Publicado: (2009)

SLX4–XPF mediates DNA damage responses to replication stress induced by DNA–protein interactions
por: Ishimoto, Riko, et al.
Publicado: (2020)

Cryo-EM structures of the XPF-ERCC1 endonuclease reveal how DNA-junction engagement disrupts an auto-inhibited conformation
por: Jones, Morgan, et al.
Publicado: (2020)

The ERCC1/XPF endonuclease is required for efficient single-strand annealing and gene conversion in mammalian cells
por: Al-Minawi, Ali Z., et al.
Publicado: (2008)

The XPF-ERCC1 Complex Is Essential for Genome Stability and Is Involved in the Mechanism of Gene Targeting in Physcomitrella patens
por: Guyon-Debast, Anouchka, et al.
Publicado: (2019)

SLX4IP acts with SLX4 and XPF–ERCC1 to promote interstrand crosslink repair
por: Zhang, Huimin, et al.
Publicado: (2019)

XPF-ERCC1 protects liver, kidney and blood homeostasis outside the canonical excision repair pathways
por: Mulderrig, Lee, et al.
Publicado: (2020)

Distribution and susceptibility of ERCC1/XPF gene polymorphisms in Han and Uygur women with breast cancer in Xinjiang, China
por: Li, Hongtao, et al.
Publicado: (2020)

Modulation of ERCC1-XPF Heterodimerization Inhibition via Structural Modification of Small Molecule Inhibitor Side-Chains
por: Weilbeer, Claudia, et al.
Publicado: (2022)

XPF–ERCC1 Blocker Improves the Therapeutic Efficacy of 5-FU- and Oxaliplatin-Based Chemoradiotherapy in Colorectal Cancer
por: Huang, Ming-Yii, et al.
Publicado: (2023)

A meiotic XPF–ERCC1-like complex recognizes joint molecule recombination intermediates to promote crossover formation
por: De Muyt, Arnaud, et al.
Publicado: (2018)

Cisplatin sensitivity of testis tumour cells is due to deficiency in interstrand-crosslink repair and low ERCC1-XPF expression
por: Usanova, Svetlana, et al.
Publicado: (2010)

The conserved XPF:ERCC1-like Zip2:Spo16 complex controls meiotic crossover formation through structure-specific DNA binding
por: Arora, Kanika, et al.
Publicado: (2019)

Single-arm, open label prospective trial to assess prediction of the role of ERCC1/XPF complex in the response of advanced NSCLC patients to platinum-based chemotherapy
por: Ganzinelli, M., et al.
Publicado: (2021)

Distinct roles of XPF-ERCC1 and Rad1-Rad10-Saw1 in replication-coupled and uncoupled inter-strand crosslink repair
por: Seol, Ja-Hwan, et al.
Publicado: (2018)

The Fanconi anemia associated protein FAAP24 uses two substrate specific binding surfaces for DNA recognition
por: Wienk, Hans, et al.
Publicado: (2013)

PCNA and XPF cooperate to distort DNA substrates
por: Hutton, Richard D., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_27p6u42bv0pvhtq1p317muq2ll