Modulation of Hypoxia-Induced Chemoresistance to Polymeric Micellar Cisplatin: The Effect of Ligand Modification of Micellar Carrier Versus Inhibition of the Mediators of Drug Resistance

Hypoxia can induce chemoresistance, which is a significant clinical obstacle in cancer therapy. Here, we assessed development of hypoxia-induced chemoresistance (HICR) against free versus polymeric cisplatin micelles in a triple negative breast cancer cell line, MDA-MB-231. We then explored two stra...

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Detalles Bibliográficos
Autores principales: Soleymani Abyaneh, Hoda, Soleimani, Amir Hassan, Vakili, Mohammad Reza, Soudy, Rania, Kaur, Kamaljit, Cuda, Francesco, Tavassoli, Ali, Lavasanifar, Afsaneh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320993/
https://www.ncbi.nlm.nih.gov/pubmed/30347860
http://dx.doi.org/10.3390/pharmaceutics10040196

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